Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Lindsay Keir; Richard J M Coward

doi:10.1007/s00467-010-1637-4

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Lindsay Keir
, Richard J M Coward^*

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

56 Citations (Scopus)

Abstract

Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).

Original language	English
Pages (from-to)	523-533
Number of pages	11
Journal	Pediatric Nephrology
Volume	26
Issue number	4
Early online date	15 Oct 2010
DOIs	https://doi.org/10.1007/s00467-010-1637-4
Publication status	Published - 1 Apr 2011

Bibliographical note

Publisher Copyright:
© IPNA 2010

Keywords

Humans
Kidney Glomerulus/metabolism
Purpura, Thrombotic Thrombocytopenic/metabolism
Thrombotic Microangiopathies/metabolism
Vascular Endothelial Growth Factor A/metabolism

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MRC Award
Coward , R. J. M. (Principal Investigator)
1/12/06 → 1/12/10
Project: Research

Cite this

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title = "Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy",

abstract = "Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).",

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AU - Coward, Richard J M

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N2 - Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).

AB - Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).

KW - Humans

KW - Kidney Glomerulus/metabolism

KW - Purpura, Thrombotic Thrombocytopenic/metabolism

KW - Thrombotic Microangiopathies/metabolism

KW - Vascular Endothelial Growth Factor A/metabolism

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M3 - Review article (Academic Journal)

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EP - 533

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 4

ER -

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Abstract

Bibliographical note

Keywords

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Projects

MRC Award

Cite this