Adverse events and safety issues associated with physical activity and exercise for adults with osteoporosis and osteopaenia: A systematic review of observational studies and an updated review of interventional studies

Setor Kunutsor, Sarah Leyland, Dawn Skelton, Laura James, Matthew Cox, Nicola Gibbons, Julie Whitney, Emma Clark

Research output: Contribution to journalArticle (Academic Journal)peer-review

198 Downloads (Pure)

Abstract

Objectives: We conducted a systematic review to identify adverse effects of physical activity and/or exercise for adults with osteoporosis/osteopenia. We synthesised evidence from observational studies, and updated three previously published systematic reviews. Methods: We searched MEDLINE, EMBASE, CINAHL, Web of Science, grey literature and reference lists of relevant studies. Selection criteria were: (1) observational studies in patients with osteoporosis/osteopenia; and (2) in accordance with the criteria used in the previous reviews. A narrative synthesis was conducted for the observational data. Random effects meta-analysis was undertaken for the review updates. Results: For the observational synthesis 14 studies were included. The majority of studies reported no adverse events, reduced incidence/improvement, or no significant change after physical activity or exercise. Activities that involved spinal flexion (certain yoga moves and sit-ups) were associated with a greater risk of vertebral fractures but these events were rare. For the update of reviews, 57 additional studies were identified. Exercise was generally associated with a greater number of minor adverse events including mild muscle/joint pain. Serious adverse events were rare and could not be attributed to the intervention. Conclusion: Patients with osteoporosis/osteopenia can safely participate in structured exercise programmes, whether at home or in supervised facilities. Systematic review registration for observational studies: PROSPERO 2017: CRD42017070551
Original languageEnglish
Pages (from-to)155-178
Number of pages24
JournalJournal of Frailty, Sarcopenia and Falls
Volume3
Issue number4
Early online date3 Dec 2018
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Osteoporosis
  • Physical activit
  • Exercise
  • Adverse events
  • Systematic review

Fingerprint Dive into the research topics of 'Adverse events and safety issues associated with physical activity and exercise for adults with osteoporosis and osteopaenia: A systematic review of observational studies and an updated review of interventional studies'. Together they form a unique fingerprint.

Cite this