TY - JOUR
T1 - Adverse events and safety issues associated with physical activity and exercise for adults with osteoporosis and osteopaenia
T2 - A systematic review of observational studies and an updated review of interventional studies
AU - Kunutsor, Setor
AU - Leyland, Sarah
AU - Skelton, Dawn
AU - James, Laura
AU - Cox, Matthew
AU - Gibbons, Nicola
AU - Whitney, Julie
AU - Clark, Emma
PY - 2018/12
Y1 - 2018/12
N2 - Objectives: We conducted a systematic review to identify adverse
effects of physical activity and/or exercise for adults with
osteoporosis/osteopenia. We synthesised evidence from observational
studies, and updated three previously published systematic reviews. Methods:
We searched MEDLINE, EMBASE, CINAHL, Web of Science, grey literature
and reference lists of relevant studies. Selection criteria were: (1)
observational studies in patients with osteoporosis/osteopenia; and (2)
in accordance with the criteria used in the previous reviews. A
narrative synthesis was conducted for the observational data. Random
effects meta-analysis was undertaken for the review updates. Results:
For the observational synthesis 14 studies were included. The majority
of studies reported no adverse events, reduced incidence/improvement, or
no significant change after physical activity or exercise. Activities
that involved spinal flexion (certain yoga moves and sit-ups) were
associated with a greater risk of vertebral fractures but these events
were rare. For the update of reviews, 57 additional studies were
identified. Exercise was generally associated with a greater number of
minor adverse events including mild muscle/joint pain. Serious adverse
events were rare and could not be attributed to the intervention. Conclusion:
Patients with osteoporosis/osteopenia can safely participate in
structured exercise programmes, whether at home or in supervised
facilities. Systematic review registration for observational studies: PROSPERO 2017: CRD42017070551
AB - Objectives: We conducted a systematic review to identify adverse
effects of physical activity and/or exercise for adults with
osteoporosis/osteopenia. We synthesised evidence from observational
studies, and updated three previously published systematic reviews. Methods:
We searched MEDLINE, EMBASE, CINAHL, Web of Science, grey literature
and reference lists of relevant studies. Selection criteria were: (1)
observational studies in patients with osteoporosis/osteopenia; and (2)
in accordance with the criteria used in the previous reviews. A
narrative synthesis was conducted for the observational data. Random
effects meta-analysis was undertaken for the review updates. Results:
For the observational synthesis 14 studies were included. The majority
of studies reported no adverse events, reduced incidence/improvement, or
no significant change after physical activity or exercise. Activities
that involved spinal flexion (certain yoga moves and sit-ups) were
associated with a greater risk of vertebral fractures but these events
were rare. For the update of reviews, 57 additional studies were
identified. Exercise was generally associated with a greater number of
minor adverse events including mild muscle/joint pain. Serious adverse
events were rare and could not be attributed to the intervention. Conclusion:
Patients with osteoporosis/osteopenia can safely participate in
structured exercise programmes, whether at home or in supervised
facilities. Systematic review registration for observational studies: PROSPERO 2017: CRD42017070551
KW - Osteoporosis
KW - Physical activit
KW - Exercise
KW - Adverse events
KW - Systematic review
U2 - 10.22540/JFSF-03-155
DO - 10.22540/JFSF-03-155
M3 - Article (Academic Journal)
C2 - 32300705
VL - 3
SP - 155
EP - 178
JO - Journal of Frailty, Sarcopenia and Falls
JF - Journal of Frailty, Sarcopenia and Falls
SN - 2459-4148
IS - 4
ER -