Aetiology of fatigue in Sri Lanka and its overlap with depression

Harriet A Ball, Athula Sumathipala, Sisira H Siribaddana, Yulia Kovas, Nick Glozier, Peter McGuffin, Matthew Hotopf

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)


BACKGROUND: Fatigue is a common symptom in Western high-income countries but is often medically unexplained and little is known about its presentation in other populations.

AIMS: To explore the epidemiology and aetiology of fatigue in Sri Lanka, and of its overlap with depression.

METHOD: A total of 4024 randomly selected twins from a population-based register in Sri Lanka (Colombo district) completed home interviews including the Chalder Fatigue Questionnaire.

RESULTS: The prevalence of fatigue was similar to that in other countries, although prolonged fatigue may be less common. There was substantial comorbidity with a screen for lifetime depression. Non-shared environmental factors made the largest contributions, although genetic/family factors also contributed. The aetiology appeared consistent across the spectrum of severity.

CONCLUSIONS: The aetiology of fatigue is broadly similar in Sri Lanka and Western high-income countries. Abnormal experiences of fatigue appear to be the extreme form of more common fatigue, rather than representing independent entities with different genetic or environmental risk factors.

Original languageEnglish
Pages (from-to)106-13
Number of pages8
JournalBritish Journal of Psychiatry
Issue number2
Publication statusPublished - Aug 2010


  • Adolescent
  • Adult
  • Comorbidity
  • Depressive Disorder/epidemiology
  • Developing Countries
  • Diseases in Twins
  • Fatigue/epidemiology
  • Female
  • Health Surveys
  • Humans
  • Male
  • Phenotype
  • Psychiatric Status Rating Scales/statistics & numerical data
  • Severity of Illness Index
  • Social Environment
  • Socioeconomic Factors
  • Sri Lanka/epidemiology
  • Surveys and Questionnaires
  • Time Factors


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