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Affective biases and their interaction with other reward-related deficits in rodent models of psychiatric disorders

Research output: Contribution to journalReview article

Original languageEnglish
Article number112051
JournalBehavioural Brain Research
Volume372
Early online date2 Jul 2019
DOIs
DateAccepted/In press - 20 Jun 2019
DateE-pub ahead of print - 2 Jul 2019
DatePublished (current) - 17 Oct 2019

Abstract

Major depressive disorder (MDD) is one of the leading global causes of disability. Symptoms of MDD can vary person to person, and current treatments often fail to alleviate the poor quality of life that patients experience. One of the two, core diagnostic criteria for MDD is the loss of interest in previously pleasurable activities, which suggests a link between the disease aetiology and reward processing. Cognitive impairments are also common in patients with MDD, and more recently, emotional processing deficits known as affective biases have been recognised as a key feature of the disorder. We consider affective biases in the context of other reward-related deficits and examine how affective biases associated with learning and memory may interact with the wider behavioural symptoms seen in MDD. We discuss recent developments in how analogues of affective biases and other aspects of reward processing can be assessed in rodents, as well as how these behaviours are influenced in models of MDD. We subsequently discuss evidence for the neurobiological mechanisms contributing to one or more reward-related deficits in preclinical models of MDD, identified using these behavioural assays. We also consider how the relationships between these selective behavioural assays and the neurobiological mechanisms for affective bias and reward processing could be used to identify potential treatment strategies.

    Research areas

  • Depression, Animal models, Affective bias, Reward processing

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Documents

  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.bbr.2019.112051 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 758 KB, PDF document

    Embargo ends: 2/07/20

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    Licence: CC BY-NC-ND

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