Projects per year
Abstract
Dendritic side chains have been used to modify the binding environment in anthracene-based synthetic carbohydrate receptors. Control of length, charge, and branching enabled the positioning of side-chain carboxylate groups in such a way that they assisted in binding substrates rather than blocking the cavity. Conformational degeneracy in the dendrimers resulted in effective preorganization despite the flexibility of the system. Strong binding was observed to glucosammonium ions in water, with Ka values up to 7000 m -1. Affinities for uncharged substrates (glucose and N-acetylglucosamine) were also enhanced, despite competition from solvent and the absence of electrostatic interactions.
Original language | English |
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Pages (from-to) | 2057-5061 |
Number of pages | 3005 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 7 |
DOIs | |
Publication status | Published - 9 Feb 2015 |
Research Groups and Themes
- BCS and TECS CDTs
- Bristol BioDesign Institute
Keywords
- synthetic biology
- Supramolecular chemistry
- Molecular recognition
- Carbohydrates
- Receptors
- Dendrimers
Fingerprint
Dive into the research topics of 'Affinity enhancement by dendritic side chains in synthetic carbohydrate receptors'. Together they form a unique fingerprint.Projects
- 2 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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From "temples" to "courtyards" for carbohydrate recognition - expanding the scope of synthetic lectins.
Davis, A. P. (Principal Investigator)
1/10/11 → 1/10/14
Project: Research
Profiles
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Professor Anthony P Davis
- School of Chemistry - Professor of Supramolecular Chemistry
Person: Academic