Affinity enhancement by dendritic side chains in synthetic carbohydrate receptors

Harry Destecroix, Charles M. Renney, Tiddo J. Mooibroek, Tom S. Carter, Patrick F N Stewart, Matthew P. Crump, Anthony P. Davis

Research output: Contribution to journalArticle (Academic Journal)peer-review

44 Citations (Scopus)

Abstract

Dendritic side chains have been used to modify the binding environment in anthracene-based synthetic carbohydrate receptors. Control of length, charge, and branching enabled the positioning of side-chain carboxylate groups in such a way that they assisted in binding substrates rather than blocking the cavity. Conformational degeneracy in the dendrimers resulted in effective preorganization despite the flexibility of the system. Strong binding was observed to glucosammonium ions in water, with Ka values up to 7000 m -1. Affinities for uncharged substrates (glucose and N-acetylglucosamine) were also enhanced, despite competition from solvent and the absence of electrostatic interactions.

Original languageEnglish
Pages (from-to)2057-5061
Number of pages3005
JournalAngewandte Chemie - International Edition
Volume54
Issue number7
DOIs
Publication statusPublished - 9 Feb 2015

Structured keywords

  • BCS and TECS CDTs

Keywords

  • Carbohydrates
  • Dendrimers
  • Molecular recognition
  • Receptors
  • Supramolecular chemistry

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