Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study

Judith S Brand; Yvonne T van der Schouw; N Charlotte Onland-Moret; Stephen J Sharp; Ken K Ong; Kay-Tee Khaw; Eva Ardanaz; Pilar Amiano; Heiner Boeing; Maria-Dolores Chirlaque; Françoise Clavel-Chapelon; Francesca L Crowe; Blandine de Lauzon-Guillain; Eric J Duell; Guy Fagherazzi; Paul W Franks; Sara Grioni; Leif C Groop; Rudolf Kaaks; Timothy J Key; Peter M Nilsson; Kim Overvad; Domenico Palli; Salvatore Panico; J Ramón Quirós; Olov Rolandsson; Carlotta Sacerdote; María-José Sánchez; Nadia Slimani; Birgit Teucher; Anne Tjonneland; Rosario Tumino; Daphne L van der A; Edith J M Feskens; Claudia Langenberg; Nita G Forouhi; Elio Riboli; Nicholas J Wareham; InterAct Consortium

doi:10.2337/dc12-1020

Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study

Judith S Brand, Yvonne T van der Schouw, N Charlotte Onland-Moret, Stephen J Sharp, Ken K Ong, Kay-Tee Khaw, Eva Ardanaz, Pilar Amiano, Heiner Boeing, Maria-Dolores Chirlaque, Françoise Clavel-Chapelon, Francesca L Crowe, Blandine de Lauzon-Guillain, Eric J Duell, Guy Fagherazzi, Paul W Franks, Sara Grioni, Leif C Groop, Rudolf Kaaks, Timothy J KeyPeter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María-José Sánchez, Nadia Slimani, Birgit Teucher, Anne Tjonneland, Rosario Tumino, Daphne L van der A, Edith J M Feskens, Claudia Langenberg, Nita G Forouhi, Elio Riboli, Nicholas J Wareham, InterAct Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

226 Citations (Scopus)

Abstract

OBJECTIVE: Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.

RESEARCH DESIGN AND METHODS: Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.

RESULTS: Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ≥55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).

CONCLUSIONS: Early menopause is associated with a greater risk of type 2 diabetes.

Original language	English
Pages (from-to)	1012-9
Number of pages	8
Journal	Diabetes Care
Volume	36
Issue number	4
DOIs	https://doi.org/10.2337/dc12-1020
Publication status	Published - Apr 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Age Factors
Diabetes Mellitus, Type 2
Female
Humans
Menopause
Middle Aged
Prospective Studies
Reproductive History
Risk Factors
Journal Article
Research Support, Non-U.S. Gov't

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10.2337/dc12-1020

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Brand, J. S., van der Schouw, Y. T., Onland-Moret, N. C., Sharp, S. J., Ong, K. K., Khaw, K.-T., Ardanaz, E., Amiano, P., Boeing, H., Chirlaque, M.-D., Clavel-Chapelon, F., Crowe, F. L., de Lauzon-Guillain, B., Duell, E. J., Fagherazzi, G., Franks, P. W., Grioni, S., Groop, L. C., Kaaks, R., ... InterAct Consortium (2013). Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study. Diabetes Care, 36(4), 1012-9. https://doi.org/10.2337/dc12-1020

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title = "Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study",

abstract = "OBJECTIVE: Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODS: Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTS: Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95\% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ≥55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).CONCLUSIONS: Early menopause is associated with a greater risk of type 2 diabetes.",

keywords = "Age Factors, Diabetes Mellitus, Type 2, Female, Humans, Menopause, Middle Aged, Prospective Studies, Reproductive History, Risk Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Brand, \{Judith S\} and \{van der Schouw\}, \{Yvonne T\} and Onland-Moret, \{N Charlotte\} and Sharp, \{Stephen J\} and Ong, \{Ken K\} and Kay-Tee Khaw and Eva Ardanaz and Pilar Amiano and Heiner Boeing and Maria-Dolores Chirlaque and Fran{\c c}oise Clavel-Chapelon and Crowe, \{Francesca L\} and \{de Lauzon-Guillain\}, Blandine and Duell, \{Eric J\} and Guy Fagherazzi and Franks, \{Paul W\} and Sara Grioni and Groop, \{Leif C\} and Rudolf Kaaks and Key, \{Timothy J\} and Nilsson, \{Peter M\} and Kim Overvad and Domenico Palli and Salvatore Panico and Quir{\'o}s, \{J Ram{\'o}n\} and Olov Rolandsson and Carlotta Sacerdote and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Nadia Slimani and Birgit Teucher and Anne Tjonneland and Rosario Tumino and \{van der A\}, \{Daphne L\} and Feskens, \{Edith J M\} and Claudia Langenberg and Forouhi, \{Nita G\} and Elio Riboli and Wareham, \{Nicholas J\} and \{InterAct Consortium\}",

year = "2013",

month = apr,

doi = "10.2337/dc12-1020",

language = "English",

volume = "36",

pages = "1012--9",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "4",

}

Brand, JS, van der Schouw, YT, Onland-Moret, NC, Sharp, SJ, Ong, KK, Khaw, K-T, Ardanaz, E, Amiano, P, Boeing, H, Chirlaque, M-D, Clavel-Chapelon, F, Crowe, FL, de Lauzon-Guillain, B, Duell, EJ, Fagherazzi, G, Franks, PW, Grioni, S, Groop, LC, Kaaks, R, Key, TJ, Nilsson, PM, Overvad, K, Palli, D, Panico, S, Quirós, JR, Rolandsson, O, Sacerdote, C, Sánchez, M-J, Slimani, N, Teucher, B, Tjonneland, A, Tumino, R, van der A, DL, Feskens, EJM, Langenberg, C, Forouhi, NG, Riboli, E, Wareham, NJ & InterAct Consortium 2013, 'Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study', Diabetes Care, vol. 36, no. 4, pp. 1012-9. https://doi.org/10.2337/dc12-1020

TY - JOUR

T1 - Age at menopause, reproductive life span, and type 2 diabetes risk

T2 - results from the EPIC-InterAct study

AU - Brand, Judith S

AU - van der Schouw, Yvonne T

AU - Onland-Moret, N Charlotte

AU - Sharp, Stephen J

AU - Ong, Ken K

AU - Khaw, Kay-Tee

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Boeing, Heiner

AU - Chirlaque, Maria-Dolores

AU - Clavel-Chapelon, Françoise

AU - Crowe, Francesca L

AU - de Lauzon-Guillain, Blandine

AU - Duell, Eric J

AU - Fagherazzi, Guy

AU - Franks, Paul W

AU - Grioni, Sara

AU - Groop, Leif C

AU - Kaaks, Rudolf

AU - Key, Timothy J

AU - Nilsson, Peter M

AU - Overvad, Kim

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Quirós, J Ramón

AU - Rolandsson, Olov

AU - Sacerdote, Carlotta

AU - Sánchez, María-José

AU - Slimani, Nadia

AU - Teucher, Birgit

AU - Tjonneland, Anne

AU - Tumino, Rosario

AU - van der A, Daphne L

AU - Feskens, Edith J M

AU - Langenberg, Claudia

AU - Forouhi, Nita G

AU - Riboli, Elio

AU - Wareham, Nicholas J

AU - InterAct Consortium

PY - 2013/4

Y1 - 2013/4

N2 - OBJECTIVE: Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODS: Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTS: Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ≥55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).CONCLUSIONS: Early menopause is associated with a greater risk of type 2 diabetes.

AB - OBJECTIVE: Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODS: Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTS: Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ≥55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).CONCLUSIONS: Early menopause is associated with a greater risk of type 2 diabetes.

KW - Age Factors

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Menopause

KW - Middle Aged

KW - Prospective Studies

KW - Reproductive History

KW - Risk Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.2337/dc12-1020

DO - 10.2337/dc12-1020

M3 - Article (Academic Journal)

C2 - 23230098

SN - 0149-5992

VL - 36

SP - 1012

EP - 1019

JO - Diabetes Care

JF - Diabetes Care

IS - 4

ER -

Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study

Abstract

UN SDGs

Keywords

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