Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project

Elaina A. MacIntyre; Ulrike Gehring; Anna Moelter; Elaine Fuertes; Claudia Kluemper; Ursula Kraemer; Ulrich Quass; Barbara Hoffmann; Mireia Gascon; Bert Brunekreef; Gerard H. Koppelman; Rob Beelen; Gerard Hoek; Matthias Birk; Johan C. de Jongste; H. A. Smit; Josef Cyrys; Olena Gruzieva; Michal Korek; Anna Bergstrom; Raymond M. Agius; Frank de Vocht; Angela Simpson; Daniela Porta; Francesco Forastiere; Chiara Badaloni; Giulia Cesaroni; Ana Esplugues; Ana Fernandez-Somoano; Aitana Lerxundi; Jordi Sunyer; Marta Cirach; Mark J. Nieuwenhuijsen; Goran Pershagen; Joachim Heinrich

doi:10.1289/ehp.1306755

Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project

Elaina A. MacIntyre
, Ulrike Gehring
, Anna Moelter
, Elaine Fuertes
, Claudia Kluemper
, Ursula Kraemer
, Ulrich Quass
, Barbara Hoffmann
, Mireia Gascon
, Bert Brunekreef
, Gerard H. Koppelman
, Rob Beelen
, Gerard Hoek
, Matthias Birk
, Johan C. de Jongste
, H. A. Smit
, Josef Cyrys
, Olena Gruzieva
, Michal Korek
, Anna Bergstrom

Raymond M. Agius, Frank de Vocht, Angela Simpson, Daniela Porta, Francesco Forastiere, Chiara Badaloni, Giulia Cesaroni, Ana Esplugues, Ana Fernandez-Somoano, Aitana Lerxundi, Jordi Sunyer, Marta Cirach, Mark J. Nieuwenhuijsen, Goran Pershagen, Joachim Heinrich^*

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

265 Citations (Scopus)

Abstract

BACKGROUND: Few studies have investigated traffic-related air pollution as a risk factor for respiratory infections during early childhood.

OBJECTIVES: We aimed to investigate the association between air pollution and pneumonia, croup, and otitis media in 10 European birth cohorts-BAMSE (Sweden), GASPII (Italy), GINIplus and LISAplus (Germany), MAAS (United Kingdom), PIAMA (the Netherlands), and four INMA cohorts (Spain)-and to derive combined effect estimates using meta-analysis.

Methods: Parent report of physician-diagnosed pneumonia, otitis media, and croup during early childhood were assessed in relation to annual average pollutant levels [nitrogen dioxide (NO2), nitrogen oxide (NOx), particulate matter

RESULTS: For pneumonia, combined adjusted odds ratios (ORs) were elevated and statistically significant for all pollutants except PM2.5 (e. g., OR = 1.30; 95% CI: 1.02, 1.65 per 10-mu g/m(3) increase in NO2 and OR = 1.76; 95% CI: 1.00, 3.09 per 10-mu g/m(3) PM10). For otitis media and croup, results were generally null across all analyses except for NO2 and otitis media (OR = 1.09; 95% CI: 1.02, 1.16 per 10-mu g/m(3)).

CONCLUSION: Our meta-analysis of 10 European birth cohorts within the ESCAPE project found consistent evidence for an association between air pollution and pneumonia in early childhood, and some evidence for an association with otitis media.

Original language	English
Pages (from-to)	107-113
Number of pages	7
Journal	Environmental Health Perspectives
Volume	122
Issue number	1
DOIs	https://doi.org/10.1289/ehp.1306755
Publication status	Published - Jan 2014

Keywords

USE REGRESSION-MODELS
1ST 2 YEARS
PARTICULATE MATTER
OTITIS-MEDIA
PM2.5 ABSORBENCY
CHILDREN YOUNGER
EXPOSURE
LIFE
OUTDOOR
HEALTH

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Professor Frank de Vocht
- frank.devochtbristol.acuk
- Applied Health Research - Professor in Epidemiology and Public Health
- Bristol Population Health Science Institute
Person: Academic , Member

Cite this

MacIntyre, E. A., Gehring, U., Moelter, A., Fuertes, E., Kluemper, C., Kraemer, U., Quass, U., Hoffmann, B., Gascon, M., Brunekreef, B., Koppelman, G. H., Beelen, R., Hoek, G., Birk, M., de Jongste, J. C., Smit, H. A., Cyrys, J., Gruzieva, O., Korek, M., ... Heinrich, J. (2014). Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project. Environmental Health Perspectives, 122(1), 107-113. https://doi.org/10.1289/ehp.1306755

@article{4e176755a9fd42d18e72f4810ec9cc24,

title = "Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project",

abstract = "BACKGROUND: Few studies have investigated traffic-related air pollution as a risk factor for respiratory infections during early childhood.OBJECTIVES: We aimed to investigate the association between air pollution and pneumonia, croup, and otitis media in 10 European birth cohorts-BAMSE (Sweden), GASPII (Italy), GINIplus and LISAplus (Germany), MAAS (United Kingdom), PIAMA (the Netherlands), and four INMA cohorts (Spain)-and to derive combined effect estimates using meta-analysis.Methods: Parent report of physician-diagnosed pneumonia, otitis media, and croup during early childhood were assessed in relation to annual average pollutant levels [nitrogen dioxide (NO2), nitrogen oxide (NOx), particulate matterRESULTS: For pneumonia, combined adjusted odds ratios (ORs) were elevated and statistically significant for all pollutants except PM2.5 (e. g., OR = 1.30; 95\% CI: 1.02, 1.65 per 10-mu g/m(3) increase in NO2 and OR = 1.76; 95\% CI: 1.00, 3.09 per 10-mu g/m(3) PM10). For otitis media and croup, results were generally null across all analyses except for NO2 and otitis media (OR = 1.09; 95\% CI: 1.02, 1.16 per 10-mu g/m(3)).CONCLUSION: Our meta-analysis of 10 European birth cohorts within the ESCAPE project found consistent evidence for an association between air pollution and pneumonia in early childhood, and some evidence for an association with otitis media.",

keywords = "USE REGRESSION-MODELS, 1ST 2 YEARS, PARTICULATE MATTER, OTITIS-MEDIA, PM2.5 ABSORBENCY, CHILDREN YOUNGER, EXPOSURE, LIFE, OUTDOOR, HEALTH",

author = "MacIntyre, \{Elaina A.\} and Ulrike Gehring and Anna Moelter and Elaine Fuertes and Claudia Kluemper and Ursula Kraemer and Ulrich Quass and Barbara Hoffmann and Mireia Gascon and Bert Brunekreef and Koppelman, \{Gerard H.\} and Rob Beelen and Gerard Hoek and Matthias Birk and \{de Jongste\}, \{Johan C.\} and Smit, \{H. A.\} and Josef Cyrys and Olena Gruzieva and Michal Korek and Anna Bergstrom and Agius, \{Raymond M.\} and \{de Vocht\}, Frank and Angela Simpson and Daniela Porta and Francesco Forastiere and Chiara Badaloni and Giulia Cesaroni and Ana Esplugues and Ana Fernandez-Somoano and Aitana Lerxundi and Jordi Sunyer and Marta Cirach and Nieuwenhuijsen, \{Mark J.\} and Goran Pershagen and Joachim Heinrich",

year = "2014",

month = jan,

doi = "10.1289/ehp.1306755",

language = "English",

volume = "122",

pages = "107--113",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "American Chemical Society",

number = "1",

}

MacIntyre, EA, Gehring, U, Moelter, A, Fuertes, E, Kluemper, C, Kraemer, U, Quass, U, Hoffmann, B, Gascon, M, Brunekreef, B, Koppelman, GH, Beelen, R, Hoek, G, Birk, M, de Jongste, JC, Smit, HA, Cyrys, J, Gruzieva, O, Korek, M, Bergstrom, A, Agius, RM, de Vocht, F, Simpson, A, Porta, D, Forastiere, F, Badaloni, C, Cesaroni, G, Esplugues, A, Fernandez-Somoano, A, Lerxundi, A, Sunyer, J, Cirach, M, Nieuwenhuijsen, MJ, Pershagen, G & Heinrich, J 2014, 'Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project', Environmental Health Perspectives, vol. 122, no. 1, pp. 107-113. https://doi.org/10.1289/ehp.1306755

TY - JOUR

T1 - Air Pollution and Respiratory Infections during Early Childhood

T2 - An Analysis of 10 European Birth Cohorts within the ESCAPE Project

AU - MacIntyre, Elaina A.

AU - Gehring, Ulrike

AU - Moelter, Anna

AU - Fuertes, Elaine

AU - Kluemper, Claudia

AU - Kraemer, Ursula

AU - Quass, Ulrich

AU - Hoffmann, Barbara

AU - Gascon, Mireia

AU - Brunekreef, Bert

AU - Koppelman, Gerard H.

AU - Beelen, Rob

AU - Hoek, Gerard

AU - Birk, Matthias

AU - de Jongste, Johan C.

AU - Smit, H. A.

AU - Cyrys, Josef

AU - Gruzieva, Olena

AU - Korek, Michal

AU - Bergstrom, Anna

AU - Agius, Raymond M.

AU - de Vocht, Frank

AU - Simpson, Angela

AU - Porta, Daniela

AU - Forastiere, Francesco

AU - Badaloni, Chiara

AU - Cesaroni, Giulia

AU - Esplugues, Ana

AU - Fernandez-Somoano, Ana

AU - Lerxundi, Aitana

AU - Sunyer, Jordi

AU - Cirach, Marta

AU - Nieuwenhuijsen, Mark J.

AU - Pershagen, Goran

AU - Heinrich, Joachim

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: Few studies have investigated traffic-related air pollution as a risk factor for respiratory infections during early childhood.OBJECTIVES: We aimed to investigate the association between air pollution and pneumonia, croup, and otitis media in 10 European birth cohorts-BAMSE (Sweden), GASPII (Italy), GINIplus and LISAplus (Germany), MAAS (United Kingdom), PIAMA (the Netherlands), and four INMA cohorts (Spain)-and to derive combined effect estimates using meta-analysis.Methods: Parent report of physician-diagnosed pneumonia, otitis media, and croup during early childhood were assessed in relation to annual average pollutant levels [nitrogen dioxide (NO2), nitrogen oxide (NOx), particulate matterRESULTS: For pneumonia, combined adjusted odds ratios (ORs) were elevated and statistically significant for all pollutants except PM2.5 (e. g., OR = 1.30; 95% CI: 1.02, 1.65 per 10-mu g/m(3) increase in NO2 and OR = 1.76; 95% CI: 1.00, 3.09 per 10-mu g/m(3) PM10). For otitis media and croup, results were generally null across all analyses except for NO2 and otitis media (OR = 1.09; 95% CI: 1.02, 1.16 per 10-mu g/m(3)).CONCLUSION: Our meta-analysis of 10 European birth cohorts within the ESCAPE project found consistent evidence for an association between air pollution and pneumonia in early childhood, and some evidence for an association with otitis media.

AB - BACKGROUND: Few studies have investigated traffic-related air pollution as a risk factor for respiratory infections during early childhood.OBJECTIVES: We aimed to investigate the association between air pollution and pneumonia, croup, and otitis media in 10 European birth cohorts-BAMSE (Sweden), GASPII (Italy), GINIplus and LISAplus (Germany), MAAS (United Kingdom), PIAMA (the Netherlands), and four INMA cohorts (Spain)-and to derive combined effect estimates using meta-analysis.Methods: Parent report of physician-diagnosed pneumonia, otitis media, and croup during early childhood were assessed in relation to annual average pollutant levels [nitrogen dioxide (NO2), nitrogen oxide (NOx), particulate matterRESULTS: For pneumonia, combined adjusted odds ratios (ORs) were elevated and statistically significant for all pollutants except PM2.5 (e. g., OR = 1.30; 95% CI: 1.02, 1.65 per 10-mu g/m(3) increase in NO2 and OR = 1.76; 95% CI: 1.00, 3.09 per 10-mu g/m(3) PM10). For otitis media and croup, results were generally null across all analyses except for NO2 and otitis media (OR = 1.09; 95% CI: 1.02, 1.16 per 10-mu g/m(3)).CONCLUSION: Our meta-analysis of 10 European birth cohorts within the ESCAPE project found consistent evidence for an association between air pollution and pneumonia in early childhood, and some evidence for an association with otitis media.

KW - USE REGRESSION-MODELS

KW - 1ST 2 YEARS

KW - PARTICULATE MATTER

KW - OTITIS-MEDIA

KW - PM2.5 ABSORBENCY

KW - CHILDREN YOUNGER

KW - EXPOSURE

KW - LIFE

KW - OUTDOOR

KW - HEALTH

U2 - 10.1289/ehp.1306755

DO - 10.1289/ehp.1306755

M3 - Article (Academic Journal)

C2 - 24149084

SN - 0091-6765

VL - 122

SP - 107

EP - 113

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 1

ER -

Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project

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Professor Frank de Vocht

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