Projects per year
Abstract
We analysed data from 23,868 men with prostate cancer and 23,051 controls from 25 studies within the international PRACTICAL consortium. Study specific associations of 68 single nucleotide polymorphisms (SNPs) in 8 alcohol-metabolising genes (Alcohol Dehydrogenases (ADHs) and Aldehyde Dehydrogenases (ALDHs)) with prostate cancer diagnosis and prostate cancer specific mortality, by grade, were assessed using logistic and Cox regression models, respectively. The data across the 25 studies were meta-analysed using fixed-effect and random effects models.
We found little evidence that variants in alcohol metabolising genes were associated with prostate cancer diagnosis. Four variants in two genes exceeded the multiple testing threshold for associations with prostate cancer mortality in fixed-effect metaanalyses. SNPs within ALDH1A2 associated with prostate cancer mortality were: rs1441817 (fixed effects hazard ratio, HRfixed=0.78; 95% confidence interval (95%CI):0.66,0.91; p-value=0.002); rs12910509, HRfixed=0.76; 95%CI:0.64,0.91; pvalue=0.003); and rs8041922 (HRfixed=0.76; 95%CI:0.64,0.91; p-value=0.002). These SNPs were in linkage disequilibrium with each other. In ALDH1B1, rs10973794 (HRfixed=1.43; 95%CI:1.14,1.79; p-value=0.002) was associated with prostate cancer mortality in men with low-grade prostate cancer.
These results suggest that alcohol consumption is unlikely to affect prostate cancer incidence, but it may influence disease progression.
Original language | English |
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Pages (from-to) | 75-85 |
Number of pages | 11 |
Journal | International Journal of Cancer |
Volume | 140 |
Issue number | 1 |
Early online date | 8 Oct 2016 |
DOIs | |
Publication status | Published - 1 Jan 2017 |
Research Groups and Themes
- ICEP
- Centre for Surgical Research
Keywords
- alcohol;
- prostate cancer
- alcohol metabolising genes
- Mendelian randomization
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Dive into the research topics of 'Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study'. Together they form a unique fingerprint.Projects
- 3 Finished
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IEU Theme 3
Windmeijer, F. (Principal Investigator), Tilling, K. M. (Researcher) & Tilling, K. M. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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IDENTIFYING POTENTIALLY MODIFIABLE LIFE-STYLE RELATED CAUSES OF CANCER
Zuccolo, L. (Principal Investigator)
1/09/06 → 1/09/10
Project: Research