Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

S Ebrahim, D Lawlor, Y Ben-Shlomo, NJ Timpson, RM Harbord, M Christensen, J Baban, M Kiessling, INM Day, TR Gaunt, G Davey Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)

Abstract

The alcohol dehydrogenase 1C gene (ADH1C) [gamma]2[gamma]2 variant reportedly interacts with moderate alcohol consumption to increase HDL-cholesterol levels and reduce coronary heart disease (CHD). We undertook replication studies in two large population cohorts of women and men. 3234 women and 1313 men with relevant genotypic and phenotypic data from two prospective population cohorts were genotyped for ADH1C variants. No association was found between ADH1C variants and HDL-cholesterol, blood pressure or incident CHD, although ADH1C was associated with alcohol consumption. There was no evidence of interactions between ADH1C variants and moderate alcohol intake on HDL-cholesterol, blood pressure or CHD incidence. Life-long women abstainers had adverse risk factor profiles. Our findings do not support the hypothesis that ADH1C variants are associated with CHD risk in people who drink moderately.
Translated title of the contributionAlcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts
Original languageEnglish
Pages (from-to)871 - 878
Number of pages8
JournalAtherosclerosis
Volume196 (2)
DOIs
Publication statusPublished - Feb 2008

Bibliographical note

Publisher: Elsevier

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