Abstract

BACKGROUND AND AIMS: There have been few longitudinal studies of association between alcohol use and cognitive functioning in young people. We aimed to examine whether alcohol use is a causal risk factor for deficient cognitive functioning in young adults.

DESIGN: Linear regression was used to examine the relationship between longitudinal latent class patterns of binge drinking and subsequent cognitive functioning. Two-sample Mendelian randomisation (MR) tested evidence for the causal relationship between alcohol use and cognitive functioning.

SETTING: South West England.

PARTICIPANTS: The observational study included 3,155 adolescents and their parents (fully adjusted models) from the Avon Longitudinal Study of Parents and Children (ALSPAC). Genetic instruments for alcohol use were based on almost 1,000,000 individuals from the GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN). Genome-wide association studies for cognitive outcomes were based on 2,500 individuals from ALSPAC.

MEASUREMENTS: Binge drinking was assessed at approximately 16, 17, 18, 21, and 23 years. Cognitive functioning comprised working memory, response inhibition, and emotion recognition assessed at 24 years of age. Ninety-nine independent genome-wide significant SNPs associated with 'number of drinks per week' were used as the genetic instrument for alcohol consumption. Potential confounders were included in the observational analyses.

FINDINGS: Four binge drinking classes were identified: 'low-risk' (41%), 'early-onset monthly' (19%), 'adult frequent' (23%), and 'early-onset frequent' (17%). The association between early-onset frequent binge drinking and cognitive functioning: working memory (b=0.09, 95%CI=-0.10 to 0.28), response inhibition (b=0.70, 95%CI=-10.55 to 11.95), and emotion recognition (b=0.01, 95%CI=-0.01 to 0.02) in comparison to low-risk drinkers was inconclusive as to whether a difference was present. Two-sample MR analyses similarly provided little evidence that alcohol use is associated with deficits in working memory using the inverse variance weight (b=0.29, 95%CI=-0.42 to 0.99), response inhibition (b=-0.32, 95%CI=-1.04 to 0.39), and emotion recognition (b=0.03, 95%CI=-0.55 to 0.61).

CONCLUSIONS: Binge drinking in adolescence and early adulthood may not be causally related to deficiencies in working memory, response inhibition, or emotion recognition in youths.

Original languageEnglish
Number of pages11
JournalAddiction
Early online date25 Apr 2020
DOIs
Publication statusE-pub ahead of print - 25 Apr 2020

Structured keywords

  • Physical and Mental Health
  • Tobacco and Alcohol

Keywords

  • Alcohol
  • ALSPAC
  • cognition
  • longitudinal latent class analysis
  • Mendelian randomization
  • prospective

Fingerprint Dive into the research topics of 'Alcohol use and cognitive functioning in young adults: improving causal inference'. Together they form a unique fingerprint.

  • Datasets

    Genome-wide association study of response inhibition

    Mahedy, L. (Creator), Suddell, S. (Creator), Skirrow, C. (Creator), Wootton, R. E. (Creator), Fernandes, G. S. (Creator), Heron, J. E. (Creator), Field, M. (Creator), Hickman, M. (Creator), Munafo, M. R. (Creator) & Munafo, M. R. (Data Manager), University of Bristol, 5 Mar 2020

    Dataset

    Genome-wide association of working memory

    Mahedy, L. (Creator), Suddell, S. (Creator), Skirrow, C. (Creator), Wootton, R. E. (Creator), Fernandes, G. S. (Creator), Heron, J. E. (Creator), Field, M. (Creator), Hickman, M. (Creator), Munafo, M. R. (Creator) & Munafo, M. R. (Data Manager), University of Bristol, 5 Mar 2020

    Dataset

    Genome-wide association study of emotion recognition

    Mahedy, L. (Creator), Suddell, S. (Creator), Skirrow, C. (Creator), Wootton, R. E. (Creator), Fernandes, G. S. (Creator), Heron, J. E. (Creator), Field, M. (Creator), Hickman, M. (Creator), Munafo, M. R. (Creator) & Munafo, M. R. (Data Manager), University of Bristol, 5 Mar 2020

    Dataset

    Cite this