Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL

Muhammad Bilal Abid*, Karan Wadera, Jenny M. Bird, Joya Pawade, David I. Marks

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
166 Downloads (Pure)


Clinical Practice Points • Secondary Malignant Histiocytosis (SMH) is an exceedingly rare, life-threatening condition that invariably occurs in the presence of an underlying monoclonal hematologic disorder. Prognosis of SMH remains dismal and there is no established treatment. • We report a case of a patient who developed SMH during induction chemotherapy for his underlying pre-B-ALL, that caused persistently high fevers and was only diagnosed by a marrow while cytopenic in phase 2 induction. He was treated with alemtuzumab-based therapy that reduced the histiocytic infiltration of the bone marrow from 80% to 15% and made him eligible to undergo T-cell replete allogeneic stem transplantation from his sibling. • This report is the first to highlight the role of alemtuzumab, an anti-CD52 monoclonal antibody, in clonal disorders originating from transdifferentiation. • The alemtuzumab-based regimen should be reserved only for carefully selected allogeneic transplant patients.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalLeukemia Research Reports
Early online date5 Dec 2017
Publication statusPublished - 1 Jan 2018


  • C/EBPα
  • PAX5
  • Pre-B-Cell Acute Lymphoblastic Leukemia (Pre-B-ALL)
  • Secondary Malignant Histiocytosis (SMH)
  • Transdifferentiation

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