Alemtuzumab-induced remission of multiple sclerosis-associated uveitis

Mark D Willis, Trevor P Pickersgill, Neil P Robertson, Richard W J Lee, Andrew D Dick, Ester Carreño

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
223 Downloads (Pure)

Abstract

PURPOSE: The purpose of the study was to report a case of multiple sclerosis (MS)-associated uveitis refractory to conventional immunosuppressants, with subsequent remission following treatment with alemtuzumab.

METHODS: Case report Patient was treated with intravenous alemtuzumab, a lymphocyte depleting anti-CD52 monoclonal antibody that has recently been approved for use in relapsing MS.

RESULTS: A 17-year-old female presented with bilateral optic neuritis and subsequently bilateral intermediate uveitis and secondary macular oedema. She was diagnosed with active relapsing MS for which she received treatment with alemtuzumab. The intraocular inflammation previously refractory to conventional immunosuppressants responded to alemtuzumab, inducing remission.

CONCLUSIONS: To our knowledge, this is the first such report of alemtuzumab treatment in MS-associated ocular inflammatory disease and may demonstrate a potential utility for this drug in related conditions.

Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalInternational Ophthalmology
Volume37
Issue number5
Early online date11 Oct 2016
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Multiple sclerosis
  • Uveitis
  • Alemtuzumab
  • Intraocular inflammation

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