Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy: a comparison of premedication with acepromazine or dexmedetomidine

Georgina L Herbert, Kelly L Bowlt, Vicky Ford-Fennah, Gwen L Covey-Crump, Joanna C Murrell

Research output: Contribution to journalArticle (Academic Journal)peer-review

39 Citations (Scopus)

Abstract

Objective  To describe alfaxalone total intravenous anaesthesia (TIVA) following premedication with buprenorphine and either acepromazine (ACP) or dexmedetomidine (DEX) in bitches undergoing ovariohysterectomy. Study design  Prospective, randomised, clinical study. Animals  Thirty-eight healthy female dogs. Methods  Following intramuscular buprenorphine (20 μg kg(-1) ) and acepromazine (0.05 mg kg(-1) ) or dexmedetomidine (approximately 10 μg kg(-1) , adjusted for body surface area), anaesthesia was induced and maintained with intravenous alfaxalone. Oxygen was administered via a suitable anaesthetic circuit. Alfaxalone infusion rate (initially 0.07 mg kg(-1)  minute(-1) ) was adjusted to maintain adequate anaesthetic depth based on clinical assessment. Alfaxalone boluses were given if required. Ventilation was assisted if necessary. Alfaxalone dose and physiologic parameters were recorded every 5 minutes. Depth of sedation after premedication, induction quality and recovery duration and quality were scored. A Student's t-test, Mann-Whitney U and Chi-squared tests determined the significance of differences between groups. Data are presented as mean ± SD or median (range). Significance was defined as p 
Original languageEnglish
JournalVeterinary Anaesthesia and Analgesia
DOIs
Publication statusPublished - 2012

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