Algal Viruses: The (Atomic) Shape of Things to Come

Christopher T Evans; Oliver Payton; Loren Picco; Michael J Allen

doi:10.3390/v10090490

Algal Viruses: The (Atomic) Shape of Things to Come

Christopher T Evans, Oliver Payton, Loren Picco, Michael J Allen

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

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Abstract

Visualization of algal viruses has been paramount to their study and understanding. The direct observation of the morphological dynamics of infection is a highly desired capability and the focus of instrument development across a variety of microscopy technologies. However, the high temporal (ms) and spatial resolution (nm) required, combined with the need to operate in physiologically relevant conditions presents a significant challenge. Here we present a short history of virus structure study and its relation to algal viruses and highlight current work, concentrating on electron microscopy and atomic force microscopy, towards the direct observation of individual algae⁻virus interactions. Finally, we make predictions towards future algal virus study direction with particular focus on the exciting opportunities offered by modern high-speed atomic force microscopy methods and instrumentation.

Original language	English
Article number	490
Number of pages	17
Journal	Viruses
Volume	10
Issue number	9
Early online date	12 Sept 2018
DOIs	https://doi.org/10.3390/v10090490
Publication status	Published - 12 Sept 2018

Research Groups and Themes

Engineering Mathematics Research Group

Keywords

algal virus
imaging
atomic force microscopy
electron microscopy
virus structure
infection dynamics

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title = "Algal Viruses: The (Atomic) Shape of Things to Come",

abstract = "Visualization of algal viruses has been paramount to their study and understanding. The direct observation of the morphological dynamics of infection is a highly desired capability and the focus of instrument development across a variety of microscopy technologies. However, the high temporal (ms) and spatial resolution (nm) required, combined with the need to operate in physiologically relevant conditions presents a significant challenge. Here we present a short history of virus structure study and its relation to algal viruses and highlight current work, concentrating on electron microscopy and atomic force microscopy, towards the direct observation of individual algae⁻virus interactions. Finally, we make predictions towards future algal virus study direction with particular focus on the exciting opportunities offered by modern high-speed atomic force microscopy methods and instrumentation.",

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AU - Picco, Loren

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N2 - Visualization of algal viruses has been paramount to their study and understanding. The direct observation of the morphological dynamics of infection is a highly desired capability and the focus of instrument development across a variety of microscopy technologies. However, the high temporal (ms) and spatial resolution (nm) required, combined with the need to operate in physiologically relevant conditions presents a significant challenge. Here we present a short history of virus structure study and its relation to algal viruses and highlight current work, concentrating on electron microscopy and atomic force microscopy, towards the direct observation of individual algae⁻virus interactions. Finally, we make predictions towards future algal virus study direction with particular focus on the exciting opportunities offered by modern high-speed atomic force microscopy methods and instrumentation.

AB - Visualization of algal viruses has been paramount to their study and understanding. The direct observation of the morphological dynamics of infection is a highly desired capability and the focus of instrument development across a variety of microscopy technologies. However, the high temporal (ms) and spatial resolution (nm) required, combined with the need to operate in physiologically relevant conditions presents a significant challenge. Here we present a short history of virus structure study and its relation to algal viruses and highlight current work, concentrating on electron microscopy and atomic force microscopy, towards the direct observation of individual algae⁻virus interactions. Finally, we make predictions towards future algal virus study direction with particular focus on the exciting opportunities offered by modern high-speed atomic force microscopy methods and instrumentation.

KW - algal virus

KW - imaging

KW - atomic force microscopy

KW - electron microscopy

KW - virus structure

KW - infection dynamics

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U2 - 10.3390/v10090490

DO - 10.3390/v10090490

M3 - Review article (Academic Journal)

C2 - 30213102

SN - 1999-4915

VL - 10

JO - Viruses

JF - Viruses

IS - 9

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ER -

Algal Viruses: The (Atomic) Shape of Things to Come

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