Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Sayad Doobary; Alastair J J Lennox

doi:10.1055/s-0040-1707143

Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Sayad Doobary, Alastair J J Lennox

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

13 Citations (Scopus)

210 Downloads (Pure)

Abstract

Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

Original language	English
Journal	SYNLETT
Early online date	18 Jun 2020
DOIs	https://doi.org/10.1055/s-0040-1707143
Publication status	E-pub ahead of print - 18 Jun 2020

Research Groups and Themes

BCS and TECS CDTs

Keywords

fluorination
alkenes
oxidation
hyper valent iodine
electrochemistry
difluorination

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10.1055/s-0040-1707143

Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Thieme Publishing at https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0040-1707143.pdf . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 1.06 MB

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Fluorofunctionalisation of alkenes via electrochemically generated hypervalent iodine reagents
Doobary, S. (Author), Lennox, A. (Supervisor) & Fermin, D. J. (Supervisor), 25 Jan 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)

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title = "Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions",

abstract = "Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.",

keywords = "fluorination, alkenes, oxidation, hyper valent iodine, electrochemistry, difluorination",

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year = "2020",

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T1 - Alkene Vicinal Difluorination

T2 - From Fluorine Gas to More Favoured Conditions

AU - Doobary, Sayad

AU - Lennox, Alastair J J

PY - 2020/6/18

Y1 - 2020/6/18

N2 - Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

AB - Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

KW - fluorination

KW - alkenes

KW - oxidation

KW - hyper valent iodine

KW - electrochemistry

KW - difluorination

U2 - 10.1055/s-0040-1707143

DO - 10.1055/s-0040-1707143

M3 - Review article (Academic Journal)

SN - 0936-5214

JO - SYNLETT

JF - SYNLETT

ER -

Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Abstract

Research Groups and Themes

Keywords

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Student theses

Fluorofunctionalisation of alkenes via electrochemically generated hypervalent iodine reagents

Cite this