Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Sayad Doobary; Alastair J J Lennox

doi:10.1055/s-0040-1707143

Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Abstract

Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

Original language	English
Journal	SYNLETT
Early online date	18 Jun 2020
DOIs	https://doi.org/10.1055/s-0040-1707143
Publication status	E-pub ahead of print - 18 Jun 2020

Keywords

fluorination
alkenes
oxidation
hyper valent iodine
electrochemistry
difluorination

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title = "Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions",

abstract = "Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.",

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N2 - Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

AB - Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.

KW - fluorination

KW - alkenes

KW - oxidation

KW - hyper valent iodine

KW - electrochemistry

KW - difluorination

U2 - 10.1055/s-0040-1707143

DO - 10.1055/s-0040-1707143

M3 - Review article (Academic Journal)

JO - SYNLETT

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