Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions

Research output: Contribution to journalReview article (Academic Journal)peer-review


Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.
Original languageEnglish
Early online date18 Jun 2020
Publication statusE-pub ahead of print - 18 Jun 2020


  • fluorination
  • alkenes
  • oxidation
  • hyper valent iodine
  • electrochemistry
  • difluorination

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