Alkyltelluro Substitution Improves the Radical-Trapping Capacity of Aromatic Amines

Jia Fei Poon, Jiajie Yan, Vijay P. Singh, Paul J Gates, Lars Engman*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
242 Downloads (Pure)

Abstract

The synthesis of a variety of aromatic amines carrying an ortho-alkyltelluro group is described. The new antioxidants quenched lipidperoxyl radicals much more efficiently than α-tocopherol and were regenerable by aqueous-phase N-acetylcysteine in a two-phase peroxidation system. The inhibition time for diaryl amine 9 b was four-fold longer than recorded with α-tocopherol. Thiol consumption in the aqueous phase was found to correlate inversely to the inhibition time and the availability of thiol is the limiting factor for the duration of antioxidant protection. The proposed mechanism for quenching of peroxyl radicals involves O-atom transfer from peroxyl to Te followed by H-atom transfer from amine to alkoxyl radical in a solvent cage.
Original languageEnglish
Pages (from-to)12891-12903
Number of pages14
JournalChemistry - A European Journal
Volume22
Issue number36
Early online date3 Aug 2016
DOIs
Publication statusPublished - 26 Aug 2016

Keywords

  • Amines
  • Antioxidants
  • Chain-breaking activity
  • Organotellurium
  • Regenerable

Fingerprint

Dive into the research topics of 'Alkyltelluro Substitution Improves the Radical-Trapping Capacity of Aromatic Amines'. Together they form a unique fingerprint.

Cite this