Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp2–sp3 Coupling of Boronic Esters with p-Arylacetylenes

Venkataraman Ganesh, Marcin Odachowski, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)
252 Downloads (Pure)

Abstract

The enantiospecific coupling of secondary and tertiary boronic esters to aromatics has been investigated. Using p-lithiated phenylacetylenes and a range of boronic esters coupling has been achieved by the addition of N-bromosuccinimide (NBS). The alkyne functionality of the intermediate boronate complex reacts with NBS triggering the 1,2-migration of the group on boron to carbon giving a dearomatized bromoallene intermediate. At this point elimination and rearomatization occurs with neopentyl boronic esters, giving the coupled products. However, using pinacol boronic esters, the boron moiety migrates to the adjacent carbon resulting in formation of ortho boron-incorporated coupled products. The synthetic utility of the boron incorporated product has been demonstrated by orthogonal transformation of both the alkyne and boronic ester functionalities.

Original languageEnglish
Pages (from-to)9752-9756
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number33
Early online date12 Jul 2017
DOIs
Publication statusPublished - 7 Aug 2017

Keywords

  • 1,2-metallate rearrangement
  • organoboron
  • phenylacetylenes
  • sp–sp coupling
  • stereospecific reactions

Fingerprint Dive into the research topics of 'Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp<sup>2</sup>–sp<sup>3</sup> Coupling of Boronic Esters with p-Arylacetylenes'. Together they form a unique fingerprint.

Cite this