Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease

Anna Maria Colacicco; Vincenzo Solfrizzi; Alessia D'Introno; Cristiano Capurso; Patrick G Kehoe; Davide Seripa; Alberto Pilotto; Andrea Santamato; Antonio Capurso; Francesco Panza

doi:10.1016/j.neurobiolaging.2007.11.015

Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease

Anna Maria Colacicco, Vincenzo Solfrizzi, Alessia D'Introno, Cristiano Capurso, Patrick G Kehoe, Davide Seripa, Alberto Pilotto, Andrea Santamato, Antonio Capurso, Francesco Panza

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotypized for alpha-2-macroglobulin (A2M) Val1000/Ile single-nucleotide polymorphism (SNP) (rs669), apolipoprotein E (APOE), and SNPs (+1073 and +1071) in the oxidized low-density lipoprotein receptor-1 (OLR1) gene on chromosome 12. A2M allele and genotype frequencies were similar between AD patients and controls, also after stratification for late onset (>/=70 years) and early onset (

Translated title of the contribution	Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease
Original language	English
Pages (from-to)	1518 - 1520
Number of pages	3
Journal	Neurobiology of Aging
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.11.015
Publication status	Published - Sept 2009

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Publisher: Elsevier

Research Groups and Themes

Cerebrovascular and Dementia Research Group

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title = "Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease",

abstract = "A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotypized for alpha-2-macroglobulin (A2M) Val1000/Ile single-nucleotide polymorphism (SNP) (rs669), apolipoprotein E (APOE), and SNPs (+1073 and +1071) in the oxidized low-density lipoprotein receptor-1 (OLR1) gene on chromosome 12. A2M allele and genotype frequencies were similar between AD patients and controls, also after stratification for late onset (>/=70 years) and early onset (",

author = "Colacicco, {Anna Maria} and Vincenzo Solfrizzi and Alessia D'Introno and Cristiano Capurso and Kehoe, {Patrick G} and Davide Seripa and Alberto Pilotto and Andrea Santamato and Antonio Capurso and Francesco Panza",

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pages = "1518 -- 1520",

journal = "Neurobiology of Aging",

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TY - JOUR

T1 - Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease

AU - Colacicco, Anna Maria

AU - Solfrizzi, Vincenzo

AU - D'Introno, Alessia

AU - Capurso, Cristiano

AU - Kehoe, Patrick G

AU - Seripa, Davide

AU - Pilotto, Alberto

AU - Santamato, Andrea

AU - Capurso, Antonio

AU - Panza, Francesco

N1 - Publisher: Elsevier

PY - 2009/9

Y1 - 2009/9

N2 - A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotypized for alpha-2-macroglobulin (A2M) Val1000/Ile single-nucleotide polymorphism (SNP) (rs669), apolipoprotein E (APOE), and SNPs (+1073 and +1071) in the oxidized low-density lipoprotein receptor-1 (OLR1) gene on chromosome 12. A2M allele and genotype frequencies were similar between AD patients and controls, also after stratification for late onset (>/=70 years) and early onset (

AB - A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotypized for alpha-2-macroglobulin (A2M) Val1000/Ile single-nucleotide polymorphism (SNP) (rs669), apolipoprotein E (APOE), and SNPs (+1073 and +1071) in the oxidized low-density lipoprotein receptor-1 (OLR1) gene on chromosome 12. A2M allele and genotype frequencies were similar between AD patients and controls, also after stratification for late onset (>/=70 years) and early onset (

U2 - 10.1016/j.neurobiolaging.2007.11.015

DO - 10.1016/j.neurobiolaging.2007.11.015

M3 - Article (Academic Journal)

C2 - 18191876

SN - 1558-1497

VL - 30

SP - 1518

EP - 1520

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 9

ER -

Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease

Abstract

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