Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis

Markus Petermann, Golo Kronenberg, Valentina Mosienko, Michael Bader, Natalia Alenina, Rainer Hellweg, Friederike Klempin

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)

Abstract

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. In this study, we used Tph2 -/- mice lacking brain serotonin to dissect the interplay between BDNF and the serotonin system in mediating the effects of antidepressant pharmacotherapy on adult neurogenesis in the hippocampus.

METHODS: Besides citalopram (CIT), we tested tianeptine (TIA), an antidepressant whose mechanism of action is not well understood. Specifically, we examined cell survival and endogenous concentrations of BDNF following daily injection of the drugs.

RESULTS: Twenty-one days of CIT, but not of TIA, led to a significant increase in the survival of newly generated cells in the dentate gyrus of wild-type mice, without a significant effect on BDNF protein levels by either treatment. In Tph2 -/- mice, adult neurogenesis was consistently increased. Furthermore, Tph2 -/- mice showed increased BDNF protein levels, which were not affected by TIA but were significantly reduced by CIT.

DISCUSSION: We conclude that the effects of CIT on adult neurogenesis are not explained by changes in BDNF protein concentrations in the hippocampus.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalPharmacopsychiatry
Volume54
Issue number3
Early online date16 Nov 2020
DOIs
Publication statusPublished - May 2021

Bibliographical note

Thieme. All rights reserved.

Keywords

  • Animals
  • Brain-Derived Neurotrophic Factor/genetics
  • Citalopram/pharmacology
  • Hippocampus/metabolism
  • Mice
  • Mice, Knockout
  • Neurogenesis

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