Altered synapse stability in the early stages of tauopathy

Johanna Jackson, Jonathan Witton, James D Johnson, Z Ahmed, Mark Ward, Andy D Randall, Michael L Hutton, John T R Isaac, Michael J O'Neill, Michael C Ashby

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)
309 Downloads (Pure)

Abstract

Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically- driven neuronal activity in pre-degenerative stages of the disease.
Original languageEnglish
Pages (from-to)3063-3068
Number of pages6
JournalCell Reports
Volume18
Issue number13
Early online date28 Mar 2017
DOIs
Publication statusPublished - 28 Mar 2017

Bibliographical note

12-Feb-17

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