Altered synapse stability in the early stages of tauopathy

Johanna Jackson; Jonathan Witton; James D Johnson; Z Ahmed; Mark Ward; Andy D Randall; Michael L Hutton; John T R Isaac; Michael J O'Neill; Michael C Ashby

doi:10.1016/j.celrep.2017.03.013

Altered synapse stability in the early stages of tauopathy

Johanna Jackson, Jonathan Witton, James D Johnson, Z Ahmed, Mark Ward, Andy D Randall, Michael L Hutton, John T R Isaac, Michael J O'Neill, Michael C Ashby

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

309 Downloads (Pure)

Abstract

Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically- driven neuronal activity in pre-degenerative stages of the disease.

Original language	English
Pages (from-to)	3063-3068
Number of pages	6
Journal	Cell Reports
Volume	18
Issue number	13
Early online date	28 Mar 2017
DOIs	https://doi.org/10.1016/j.celrep.2017.03.013
Publication status	Published - 28 Mar 2017

Bibliographical note

12-Feb-17

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10.1016/j.celrep.2017.03.013

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Template neuronal networks in developing neocortex
Ashby, M. C.
3/01/13 → 3/05/16
Project: Research

Dr Michael C Ashby
- M.C.Ashby@bristol.ac.uk
- School of Physiology, Pharmacology & Neuroscience - Senior Lecturer
- Fundamental Bioscience
- Bristol Neuroscience
Person: Academic , Member

Cite this

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title = "Altered synapse stability in the early stages of tauopathy",

abstract = "Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically- driven neuronal activity in pre-degenerative stages of the disease.",

author = "Johanna Jackson and Jonathan Witton and Johnson, {James D} and Z Ahmed and Mark Ward and Randall, {Andy D} and Hutton, {Michael L} and Isaac, {John T R} and O'Neill, {Michael J} and Ashby, {Michael C}",

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Altered synapse stability in the early stages of tauopathy. / Jackson, Johanna; Witton, Jonathan; Johnson, James D; Ahmed, Z; Ward, Mark; Randall, Andy D; Hutton, Michael L; Isaac, John T R; O'Neill, Michael J; Ashby, Michael C.

In: Cell Reports, Vol. 18, No. 13, 28.03.2017, p. 3063-3068.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Jackson, Johanna

AU - Witton, Jonathan

AU - Johnson, James D

AU - Ahmed, Z

AU - Ward, Mark

AU - Randall, Andy D

AU - Hutton, Michael L

AU - Isaac, John T R

AU - O'Neill, Michael J

AU - Ashby, Michael C

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N2 - Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically- driven neuronal activity in pre-degenerative stages of the disease.

AB - Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically- driven neuronal activity in pre-degenerative stages of the disease.

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DO - 10.1016/j.celrep.2017.03.013

M3 - Article (Academic Journal)

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EP - 3068

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 13

ER -

Altered synapse stability in the early stages of tauopathy

Abstract

Bibliographical note

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Template neuronal networks in developing neocortex

Dr Michael C Ashby

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