Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

Paul W May, A Hopper, James M Dugan, AA Gill, OJL Fox, JW Haycock, Frederik Claeyssens

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)

Abstract

In this study, we report the production of amine functionalized nanodiamond. The amine
functionalized nanodiamond forms a conformal monolayer on a negatively charged surface
produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were
studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybrid
cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for
between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann
cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating
the potential of the coating for applications in the treatment of peripheral nerve injury.
Original languageEnglish
Pages (from-to)045009
Number of pages11
JournalBiomedical Materials (Bristol)
Volume9
DOIs
Publication statusPublished - 2014

Keywords

  • Diamondlike carbon
  • Neurons

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