Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

Paul W May; A Hopper; James M Dugan; AA Gill; OJL Fox; JW Haycock; Frederik Claeyssens

doi:10.1088/1748-6041/9/4/045009

Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

Paul W May, A Hopper, James M Dugan, AA Gill, OJL Fox, JW Haycock, Frederik Claeyssens

Research output: Contribution to journal › Article (Academic Journal) › peer-review

45 Citations (Scopus)

Abstract

In this study, we report the production of amine functionalized nanodiamond. The amine
functionalized nanodiamond forms a conformal monolayer on a negatively charged surface
produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were
studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybrid
cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for
between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann
cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating
the potential of the coating for applications in the treatment of peripheral nerve injury.

Original language	English
Pages (from-to)	045009
Number of pages	11
Journal	Biomedical Materials (Bristol)
Volume	9
DOIs	https://doi.org/10.1088/1748-6041/9/4/045009
Publication status	Published - 2014

Keywords

Diamondlike carbon
Neurons

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45 Citations
1 Article (Academic Journal)
1 Review article (Academic Journal)

Diamond thin films: giving biomedical applications a new shine
Nistor, P. & May, P., Sep 2017, In: Journal of the Royal Society Interface. 14, 134, 15 p., 20170382.
Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access
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56 Citations (Scopus)

302 Downloads (Pure)
Photochemically modified diamond-like carbon surfaces for neural interfaces
May, P., Hopper, A. P., Dugan, J. M., Gill, A. A., Haycock, J. W., Claeyssens, F., Regan, E. M. & Kelly, S., 8 Sep 2015, In: Materials Science and Engineering C. 58, p. 1199-1206
Research output: Contribution to journal › Article (Academic Journal) › peer-review
8 Citations (Scopus)

1 Finished

CVD DIAMOND AS A SUBSTRATE FOR BIOLOGICAL CELL GROWTH - TOWARDS DIRECT BRAIN-COMPUTER INTERFACES
May, P. W.
18/02/13 → 18/06/16
Project: Research

Cite this

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title = "Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth",

abstract = "In this study, we report the production of amine functionalized nanodiamond. The aminefunctionalized nanodiamond forms a conformal monolayer on a negatively charged surfaceproduced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces werestudied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybridcells were successfully cultured upon amine functionalized nanodiamond coated surfaces forbetween 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwanncells isolated from Wistar rats were also successfully cultured over a period of 21 d illustratingthe potential of the coating for applications in the treatment of peripheral nerve injury.",

keywords = "Diamondlike carbon, Neurons",

author = "May, {Paul W} and A Hopper and Dugan, {James M} and AA Gill and OJL Fox and JW Haycock and Frederik Claeyssens",

year = "2014",

doi = "10.1088/1748-6041/9/4/045009",

language = "English",

volume = "9",

pages = "045009",

journal = "Biomedical Materials (Bristol)",

issn = "1748-6041",

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TY - JOUR

T1 - Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

AU - May, Paul W

AU - Hopper, A

AU - Dugan, James M

AU - Gill, AA

AU - Fox, OJL

AU - Haycock, JW

AU - Claeyssens, Frederik

PY - 2014

Y1 - 2014

N2 - In this study, we report the production of amine functionalized nanodiamond. The aminefunctionalized nanodiamond forms a conformal monolayer on a negatively charged surfaceproduced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces werestudied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybridcells were successfully cultured upon amine functionalized nanodiamond coated surfaces forbetween 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwanncells isolated from Wistar rats were also successfully cultured over a period of 21 d illustratingthe potential of the coating for applications in the treatment of peripheral nerve injury.

AB - In this study, we report the production of amine functionalized nanodiamond. The aminefunctionalized nanodiamond forms a conformal monolayer on a negatively charged surfaceproduced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces werestudied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybridcells were successfully cultured upon amine functionalized nanodiamond coated surfaces forbetween 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwanncells isolated from Wistar rats were also successfully cultured over a period of 21 d illustratingthe potential of the coating for applications in the treatment of peripheral nerve injury.

KW - Diamondlike carbon

KW - Neurons

U2 - 10.1088/1748-6041/9/4/045009

DO - 10.1088/1748-6041/9/4/045009

M3 - Article (Academic Journal)

C2 - 25029630

VL - 9

SP - 045009

JO - Biomedical Materials (Bristol)

JF - Biomedical Materials (Bristol)

SN - 1748-6041

ER -

Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

Abstract

Keywords

Access to Document

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Research output

Diamond thin films: giving biomedical applications a new shine

Photochemically modified diamond-like carbon surfaces for neural interfaces

Projects

CVD DIAMOND AS A SUBSTRATE FOR BIOLOGICAL CELL GROWTH - TOWARDS DIRECT BRAIN-COMPUTER INTERFACES

Cite this