Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report

James H Briggs; Will G B Singleton; Margaret M Burke; Lorraine A Hart; Robert J Parker

doi:10.4076/1757-1626-2-6963

Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report

James H Briggs, Will G B Singleton, Margaret M Burke, Lorraine A Hart, Robert J Parker

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Abstract

A 66-year-old man with a diagnosis of monoclonal gammopathy of unknown significance was referred for investigation of bilateral transudative pleural effusions by the cardiology team. Echocardiography, myocardial perfusion scanning and left heart catheterisation were all normal or non diagnostic. Given significant occupational asbestos exposure in his twenties he underwent thoracoscopic pleural biopsy. This showed fibrous inflammation only. He subsequently developed proteinuria and peripheral oedema. Reanalysis of the pleural biopsy specimen for amyloidosis was positive. Pleural disease is an uncommon presentation of systemic amyloidosis. The aetiology of the pleural effusions is unclear and is not simply a consequence of cardiac or renal impairment.

Original language	English
Pages (from-to)	6963
Journal	Cases Journal
Volume	2
DOIs	https://doi.org/10.4076/1757-1626-2-6963
Publication status	Published - 2009

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title = "Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report",

abstract = "A 66-year-old man with a diagnosis of monoclonal gammopathy of unknown significance was referred for investigation of bilateral transudative pleural effusions by the cardiology team. Echocardiography, myocardial perfusion scanning and left heart catheterisation were all normal or non diagnostic. Given significant occupational asbestos exposure in his twenties he underwent thoracoscopic pleural biopsy. This showed fibrous inflammation only. He subsequently developed proteinuria and peripheral oedema. Reanalysis of the pleural biopsy specimen for amyloidosis was positive. Pleural disease is an uncommon presentation of systemic amyloidosis. The aetiology of the pleural effusions is unclear and is not simply a consequence of cardiac or renal impairment.",

author = "Briggs, {James H} and Singleton, {Will G B} and Burke, {Margaret M} and Hart, {Lorraine A} and Parker, {Robert J}",

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T1 - Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations

T2 - a case report

AU - Briggs, James H

AU - Singleton, Will G B

AU - Burke, Margaret M

AU - Hart, Lorraine A

AU - Parker, Robert J

PY - 2009

Y1 - 2009

N2 - A 66-year-old man with a diagnosis of monoclonal gammopathy of unknown significance was referred for investigation of bilateral transudative pleural effusions by the cardiology team. Echocardiography, myocardial perfusion scanning and left heart catheterisation were all normal or non diagnostic. Given significant occupational asbestos exposure in his twenties he underwent thoracoscopic pleural biopsy. This showed fibrous inflammation only. He subsequently developed proteinuria and peripheral oedema. Reanalysis of the pleural biopsy specimen for amyloidosis was positive. Pleural disease is an uncommon presentation of systemic amyloidosis. The aetiology of the pleural effusions is unclear and is not simply a consequence of cardiac or renal impairment.

AB - A 66-year-old man with a diagnosis of monoclonal gammopathy of unknown significance was referred for investigation of bilateral transudative pleural effusions by the cardiology team. Echocardiography, myocardial perfusion scanning and left heart catheterisation were all normal or non diagnostic. Given significant occupational asbestos exposure in his twenties he underwent thoracoscopic pleural biopsy. This showed fibrous inflammation only. He subsequently developed proteinuria and peripheral oedema. Reanalysis of the pleural biopsy specimen for amyloidosis was positive. Pleural disease is an uncommon presentation of systemic amyloidosis. The aetiology of the pleural effusions is unclear and is not simply a consequence of cardiac or renal impairment.

U2 - 10.4076/1757-1626-2-6963

DO - 10.4076/1757-1626-2-6963

M3 - Article (Academic Journal)

C2 - 19829885

VL - 2

SP - 6963

JO - Cases Journal

JF - Cases Journal

ER -

Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report

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