Objective: Endovascular revascularization in atherosclerotic renal artery stenosis (ARAS) has dominated during the last 15 years with surgery relegated mostly to back-up for failed endovascular procedures. This study examines the available outcome evidence to determine what rote open surgery should have in comparison to endovascular treatment in the management of ARAS.
Method: Of 183 papers Listed in PubMed, the USNLM and the Cochrane library, (1975-2004) 47, dealing with outcomes of surgical and endovascular treatments (evidence levels 2b and 3) were selected. Endovascular included 1750 patients in 16 prospective non-randomised (PNRT) and 5 retrospective (RET) studies. Surgical included 2314 patients in 4 PNRTs and 17 RETs. Outcome data were subjected to meta-regression analysis weighted according to the inverse variance method.
Results: Mean maximum ages were 79.4 yrs (SD 6.9) for surgical and 83.6 yrs (SD 3.8) for endovascutar studies. Primary technical success was similar. Endovascular patency declined by 0.26%/month (95% CI: 0.04-0.48, p = 0.03). Surgical studies showed greater improvement for hypertension control by 21% (95% CI: 9-33%, p = 0.001) and for renal function by 34% (95% CI: 18-54%, p <0.001), as well as a higher creatinine reduction by 32 mu mol/L (95% CI: 7-57 mu mol/L, p <0.014). A higher excess surgical mortality, 3.1% (95% CI: 1.8-4.4%, p <0.001) became insignificant, 0.18% (95% CI: 0.7-1.1, p = 0.70) when concomitant aortic surgery was excluded.
Conclusion: This data shows a marked and durable clinical benefit for surgery. These findings question the endovascutar predominance in intervention in ARAS and highlight the need for a carefully designed prospective randomised comparison to define the roles of endovascular and surgical renal revascularization. (C) 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. ALL rights reserved.
|Number of pages||10|
|Journal||European Journal of Vascular and Endovascular Surgery|
|Publication status||Published - Dec 2009|
- Atherosclerotic renal artery stenosis
- Surgical revascularization
- Stent revascularization
- Renal function
- RENOVASCULAR DISEASE
- STENT PLACEMENT
- ISCHEMIC NEPHROPATHY