An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study

Carmel M McEniery, Michael Spratt, Margaret Munnery, John Yarnell, Gordon D Lowe, Ann Rumley, John Gallacher, Yoav Ben-Shlomo, John R Cockcroft, Ian B Wilkinson

Research output: Contribution to journalArticle (Academic Journal)peer-review

150 Citations (Scopus)

Abstract

Arterial stiffness is an important determinant of cardiovascular risk. The precise risk factors for arterial stiffening remain unclear. We aimed to identify potential risk factors using prospective exposure data from the Caerphilly Prospective Study. Aortic pulse wave velocity and augmentation index were measured in 825 men and related to current (2004) and baseline (1979-1988) anthropometric, hemodynamic, and biochemical factors. The mean age of the men was 74 years, with an average follow-up of 20 years. The only independent baseline predictors of current velocity were pulse pressure (standardized beta-coefficient: 0.58), C-reactive protein (0.35), glucose (0.25), and waist circumference (0.23). The sole baseline predictor of current augmentation index was fibrinogen (0.78). After additional adjustment for the corresponding current risk factor, pulse wave velocity was best related to cumulative exposure to C-reactive protein, whereas augmentation index was most strongly related to current levels. Velocity was also more strongly correlated with baseline levels of triglycerides and smoking but with current waist circumference. The pulse pressure heart rate product assessed over the whole of 20 years was independently correlated with aortic pulse wave velocity but not augmentation index. Other than blood pressure, established cardiovascular risk factors have only a modest effect on aortic stiffness and wave reflection. Inflammation and the level of repetitive cyclic stress are important predictors of aortic stiffness, whereas wave reflection is predicted by acute inflammation only. Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly.
Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalHypertension
Volume56
Issue number1
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Questionnaires
  • Vascular Resistance
  • Aorta
  • Humans
  • Prognosis
  • Aged
  • Great Britain
  • Risk Assessment
  • Cross-Sectional Studies
  • Heart Rate
  • Prospective Studies
  • Risk Factors
  • Incidence
  • Sphygmomanometers
  • Cardiovascular Diseases
  • Follow-Up Studies
  • Middle Aged
  • Time Factors
  • Pulsatile Flow
  • Male

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