TY - JOUR
T1 - An analysis of substrate binding interactions in the heme peroxidase enzymes
T2 - A structural perspective
AU - Gumiero, Andrea
AU - Murphy, Emma J.
AU - Metcalfe, Clive L.
AU - Moody, Peter C.E.
AU - Raven, Emma Lloyd
PY - 2010/8/1
Y1 - 2010/8/1
N2 - The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.
AB - The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.
KW - Ascorbate peroxidase
KW - Cytochrome c peroxidase
KW - Heme
KW - Horseradish peroxidase
KW - Peroxidase
KW - Substrate
UR - http://www.scopus.com/inward/record.url?scp=77954310525&partnerID=8YFLogxK
U2 - 10.1016/j.abb.2010.02.015
DO - 10.1016/j.abb.2010.02.015
M3 - Review article (Academic Journal)
C2 - 20206594
AN - SCOPUS:77954310525
VL - 500
SP - 13
EP - 20
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 1
ER -