An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective

Andrea Gumiero, Emma J. Murphy, Clive L. Metcalfe, Peter C.E. Moody, Emma Lloyd Raven*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

51 Citations (Scopus)

Abstract

The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume500
Issue number1
DOIs
Publication statusPublished - 1 Aug 2010

Keywords

  • Ascorbate peroxidase
  • Cytochrome c peroxidase
  • Heme
  • Horseradish peroxidase
  • Peroxidase
  • Substrate

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