An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective

Andrea Gumiero; Emma J. Murphy; Clive L. Metcalfe; Peter C.E. Moody; Emma Lloyd Raven

doi:10.1016/j.abb.2010.02.015

An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective

Andrea Gumiero
, Emma J. Murphy
, Clive L. Metcalfe
, Peter C.E. Moody
, Emma Lloyd Raven^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

78 Citations (Scopus)

Abstract

The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.

Original language	English
Pages (from-to)	13-20
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	500
Issue number	1
DOIs	https://doi.org/10.1016/j.abb.2010.02.015
Publication status	Published - 1 Aug 2010

Research Groups and Themes

Inorganic & Materials

Keywords

Ascorbate peroxidase
Cytochrome c peroxidase
Heme
Horseradish peroxidase
Peroxidase
Substrate

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title = "An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective",

abstract = "The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.",

keywords = "Ascorbate peroxidase, Cytochrome c peroxidase, Heme, Horseradish peroxidase, Peroxidase, Substrate",

author = "Andrea Gumiero and Murphy, \{Emma J.\} and Metcalfe, \{Clive L.\} and Moody, \{Peter C.E.\} and Raven, \{Emma Lloyd\}",

year = "2010",

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doi = "10.1016/j.abb.2010.02.015",

language = "English",

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journal = "Archives of Biochemistry and Biophysics",

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TY - JOUR

T1 - An analysis of substrate binding interactions in the heme peroxidase enzymes

T2 - A structural perspective

AU - Gumiero, Andrea

AU - Murphy, Emma J.

AU - Metcalfe, Clive L.

AU - Moody, Peter C.E.

AU - Raven, Emma Lloyd

PY - 2010/8/1

Y1 - 2010/8/1

N2 - The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.

AB - The interactions of heme peroxidase enzymes with their substrates have been studied for many years, but only in the last decade or so has structural information begun to appear. This review looks at crystal structures for a number of heme peroxidases in complex with a number of (mainly organic) substrates. It examines the nature and location of the binding interaction, and explores functional similarities and differences across the family.

KW - Ascorbate peroxidase

KW - Cytochrome c peroxidase

KW - Heme

KW - Horseradish peroxidase

KW - Peroxidase

KW - Substrate

UR - https://www.scopus.com/pages/publications/77954310525

U2 - 10.1016/j.abb.2010.02.015

DO - 10.1016/j.abb.2010.02.015

M3 - Review article (Academic Journal)

C2 - 20206594

AN - SCOPUS:77954310525

SN - 0003-9861

VL - 500

SP - 13

EP - 20

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 1

ER -

An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective

Abstract

Research Groups and Themes

Keywords

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