An assessment of the portability of ancestry informative markers between human populations

Sean Myles, Mark Stoneking, Nicholas J Timpson

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Abstract

Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these effects. Subsets of markers that are highly-differentiated between populations, ancestry-informative markers (AIMs), have been used to correct for population stratification. Often AIMs are discovered in one set of populations and then employed in a different set of populations. The underlying assumption in these cases is that the population under study has the same substructure as the population in which the AIMs were discovered. The present study assesses this assumption and evaluates the portability between worldwide populations of 10 SNPs found to be highly-differentiated within Britain (BritAIMs).
Original languageEnglish
Pages (from-to)45
JournalBMC Medical Genomics
Volume2
DOIs
Publication statusPublished - 2009

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