An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

Tim Ravasi, Julian Gough, consortium FANTOM

Research output: Contribution to journalArticle (Academic Journal)peer-review

589 Citations (Scopus)

Abstract

Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
Translated title of the contributionAn Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Original languageEnglish
Pages (from-to)744-752
Number of pages9
JournalCell
Volume140
Issue number5
DOIs
Publication statusPublished - Mar 2010

Bibliographical note

Other identifier: 2001180

Fingerprint

Dive into the research topics of 'An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man'. Together they form a unique fingerprint.

Cite this