An Efficient Protocol for Synthesis of Pyrazolo[3,4-a]acridines

Satheeshkumar Rajendran, Werner Kaminsky, Hazel A. Sparkes, Karnam Jayarampillai Rajendra Prasad

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
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A new class of pyrazolo[3,4-a]acridines have been prepared, the synthon acridones were obtained in very good yield by one pot reaction of 2-amino-5-chloro or nitro substituted benzophenones with 1,3-cyclic diketones in the presence of freshly prepared Eaton's reagent without solvent, using Friedländer synthesis. The intermediates were reacted with ethylformate followed by hydrazine hydrate to afford pyrazolo[3,4-a]acridines. All of the compounds were purified by recrystallization only, and no chromatographic work-up was required. The structures of the synthesized compounds were deduced by spectroscopic techniques, including single crystal X-ray diffraction.
Original languageEnglish
JournalSynthetic Communications
Issue number19
Early online date22 Jul 2015
Publication statusPublished - Oct 2015

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