An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate

Sven P. Fritz, Juan F. Moya, Matthew G. Unthank, Eoghan M. McGarrigle*, Varinder K. Aggarwal

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)

Abstract

Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesis of an oxetane.

Original languageEnglish
Pages (from-to)1584-1590
Number of pages7
JournalSynthesis (Germany)
Volume44
Issue number10
DOIs
Publication statusPublished - May 2012

Keywords

  • annulations
  • cyclizations
  • heterocycles
  • sulfur
  • ylides
  • VINYL SULFONIUM SALTS
  • ASYMMETRIC-SYNTHESIS
  • DRUG DISCOVERY
  • AZETIDINE-2-CARBOXYLIC ACID
  • CYCLOPROPANATION REACTIONS
  • CONVENIENT METHOD
  • CHIRAL CATALYSTS
  • TANDEM REACTIONS
  • AMINO-ALCOHOLS
  • DERIVATIVES

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