An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales

D. De Angelis; M. Sweeting; A. E. Ades; Matthew Hickman; V. Hope; M. Ramsay

doi:10.1177/0962280208094691

An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales

D. De Angelis, M. Sweeting, A. E. Ades, Matthew Hickman, V. Hope, M. Ramsay

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Abstract

Abstract In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.

Translated title of the contribution	An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales
Original language	English
Pages (from-to)	361-379
Number of pages	20
Journal	Statistical Methods in Medical Research
Volume	18
Issue number	4
DOIs	https://doi.org/10.1177/0962280208094691
Publication status	Published - Aug 2009

Bibliographical note

Publisher: Sage Publishing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/0962280208094691

http://smm.sagepub.com/cgi/reprint/18/4/361

Handle.net

Persistent link

Cite this

@article{656fb9545a7e40c783a106d0e6088f15,

title = "An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales",

abstract = "Abstract In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.",

author = "{De Angelis}, D. and M. Sweeting and Ades, {A. E.} and Matthew Hickman and V. Hope and M. Ramsay",

note = "Publisher: Sage Publishing",

year = "2009",

month = aug,

doi = "10.1177/0962280208094691",

language = "English",

volume = "18",

pages = "361--379",

journal = "Statistical Methods in Medical Research",

issn = "1477-0334",

publisher = "SAGE Publications Ltd",

number = "4",

}

TY - JOUR

T1 - An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales

AU - De Angelis, D.

AU - Sweeting, M.

AU - Ades, A. E.

AU - Hickman, Matthew

AU - Hope, V.

AU - Ramsay, M.

N1 - Publisher: Sage Publishing

PY - 2009/8

Y1 - 2009/8

N2 - Abstract In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.

AB - Abstract In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.

U2 - 10.1177/0962280208094691

DO - 10.1177/0962280208094691

M3 - Article (Academic Journal)

C2 - 19036917

SN - 1477-0334

VL - 18

SP - 361

EP - 379

JO - Statistical Methods in Medical Research

JF - Statistical Methods in Medical Research

IS - 4

ER -

An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales

Abstract

Bibliographical note

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this