An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales

D. De Angelis, M. Sweeting, A. E. Ades, Matthew Hickman, V. Hope, M. Ramsay

Research output: Contribution to journalArticle (Academic Journal)peer-review

58 Citations (Scopus)

Abstract

Abstract In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.
Translated title of the contributionAn evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales
Original languageEnglish
Pages (from-to)361-379
Number of pages20
JournalStatistical Methods in Medical Research
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 2009

Bibliographical note

Publisher: Sage Publishing

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