An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

C Williams; H Hoppe; D Rezgui; M Strickland; B.E Forbes; Frank Grutzner; S Frago; Rosamund Z. Ellis; P Wattana-Amorn; S.N Prince; O.J Zaccheo; Andrew J. Mungall; Y Jones; Catherine M. Nolan; M.P Crump; A.B Hassan

doi:10.1126/science.1228633

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

C Williams, H Hoppe, D Rezgui, M Strickland, B.E Forbes, Frank Grutzner, S Frago, Rosamund Z. Ellis, P Wattana-Amorn, S.N Prince, O.J Zaccheo, Andrew J. Mungall, Y Jones, Catherine M. Nolan, M.P Crump, A.B Hassan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

38 Citations (Scopus)

Translated title of the contribution	To be confirmed
Original language	English
Pages (from-to)	1209-1213
Number of pages	5
Journal	Science
Volume	338
Issue number	6111
DOIs	https://doi.org/10.1126/science.1228633
Publication status	Published - Nov 2012

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Organic & Biological

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http://www.sciencemag.org/content/338/6111/1209

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Williams, C., Hoppe, H., Rezgui, D., Strickland, M., Forbes, B. E., Grutzner, F., Frago, S., Ellis, R. Z., Wattana-Amorn, P., Prince, S. N., Zaccheo, O. J., Mungall, A. J., Jones, Y., Nolan, C. M., Crump, M. P., & Hassan, A. B. (2012). An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338(6111), 1209-1213. https://doi.org/10.1126/science.1228633

@article{7093fe36cd87458591d32a0c9b6ea09c,

title = "An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.",

author = "C Williams and H Hoppe and D Rezgui and M Strickland and B.E Forbes and Frank Grutzner and S Frago and Ellis, \{Rosamund Z.\} and P Wattana-Amorn and S.N Prince and O.J Zaccheo and Mungall, \{Andrew J.\} and Y Jones and Nolan, \{Catherine M.\} and M.P Crump and A.B Hassan",

year = "2012",

month = nov,

doi = "10.1126/science.1228633",

language = "English",

volume = "338",

pages = "1209--1213",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6111",

}

Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Forbes, BE, Grutzner, F, Frago, S, Ellis, RZ, Wattana-Amorn, P, Prince, SN, Zaccheo, OJ, Mungall, AJ, Jones, Y, Nolan, CM, Crump, MP & Hassan, AB 2012, 'An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.', Science, vol. 338, no. 6111, pp. 1209-1213. https://doi.org/10.1126/science.1228633

TY - JOUR

T1 - An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

AU - Williams, C

AU - Hoppe, H

AU - Rezgui, D

AU - Strickland, M

AU - Forbes, B.E

AU - Grutzner, Frank

AU - Frago, S

AU - Ellis, Rosamund Z.

AU - Wattana-Amorn, P

AU - Prince, S.N

AU - Zaccheo, O.J

AU - Mungall, Andrew J.

AU - Jones, Y

AU - Nolan, Catherine M.

AU - Crump, M.P

AU - Hassan, A.B

PY - 2012/11

Y1 - 2012/11

UR - https://www.scopus.com/pages/publications/84870181772

U2 - 10.1126/science.1228633

DO - 10.1126/science.1228633

M3 - Article (Academic Journal)

C2 - 23197533

SN - 0036-8075

VL - 338

SP - 1209

EP - 1213

JO - Science

JF - Science

IS - 6111

ER -

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

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Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

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