An exploration of the reactivity of singlet oxygen with biomolecular constituents

Barbara Marchetti, Tolga N V Karsili*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)
282 Downloads (Pure)


The thermal reaction between biomolecules and singlet oxygen (1O2) is important for rendering the genetic material within toxic cells inactive. Here we present results obtained from state-of-the-art multi-reference computational methods that reveal the mechanistic details of the reaction between 1O2 and two exemplary biomolecular systems: guanine (Gua) and histidine (His). The results highlight the splitting of the doubly degenerate 1Δg state of O2 upon complexation and the essentially barrierless potential energy profile of the thermally allowed cycloaddition reaction when the O2 molecule is in its lower energy 1Δg state.

Original languageEnglish
Pages (from-to)10996-10999
Number of pages4
JournalChemical Communications
Issue number73
Early online date11 Aug 2016
Publication statusPublished - 21 Sept 2016


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