An interactive genome browser of association results from the UK10K cohorts project

Matthias Geihs; Ying Yan; Klaudia Walter; Jie Huang; Yasin Memari; Josine L Min; Daniel Mead; Tim J Hubbard; Nicholas J Timpson; Thomas A Down; Nicole Soranzo; UK10K Consortium

doi:10.1093/bioinformatics/btv491

An interactive genome browser of association results from the UK10K cohorts project

Matthias Geihs, Ying Yan, Klaudia Walter, Jie Huang, Yasin Memari, Josine L Min, Daniel Mead, Tim J Hubbard, Nicholas J Timpson, Thomas A Down, Nicole Soranzo, UK10K Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

Abstract

UNLABELLED: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project.

AVAILABILITY AND IMPLEMENTATION: The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.

CONTACT: [email protected] or [email protected]

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Original language	English
Pages (from-to)	4029-31
Number of pages	3
Journal	Bioinformatics
Volume	31
Issue number	24
DOIs	https://doi.org/10.1093/bioinformatics/btv491
Publication status	Published - 15 Dec 2015

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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

Cite this

@article{4da58b408fe040dcb3a37cc4aa1f1cd8,

title = "An interactive genome browser of association results from the UK10K cohorts project",

abstract = "UNLABELLED: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project.AVAILABILITY AND IMPLEMENTATION: The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.CONTACT: [email protected] or [email protected] INFORMATION: Supplementary data are available at Bioinformatics online.",

author = "Matthias Geihs and Ying Yan and Klaudia Walter and Jie Huang and Yasin Memari and Min, {Josine L} and Daniel Mead and Hubbard, {Tim J} and Timpson, {Nicholas J} and Down, {Thomas A} and Nicole Soranzo and {UK10K Consortium}",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press.",

year = "2015",

month = dec,

day = "15",

doi = "10.1093/bioinformatics/btv491",

language = "English",

volume = "31",

pages = "4029--31",

journal = "Bioinformatics",

issn = "1367-4811",

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TY - JOUR

T1 - An interactive genome browser of association results from the UK10K cohorts project

AU - Geihs, Matthias

AU - Yan, Ying

AU - Walter, Klaudia

AU - Huang, Jie

AU - Memari, Yasin

AU - Min, Josine L

AU - Mead, Daniel

AU - Hubbard, Tim J

AU - Timpson, Nicholas J

AU - Down, Thomas A

AU - Soranzo, Nicole

AU - UK10K Consortium

PY - 2015/12/15

Y1 - 2015/12/15

N2 - UNLABELLED: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project.AVAILABILITY AND IMPLEMENTATION: The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.CONTACT: [email protected] or [email protected] INFORMATION: Supplementary data are available at Bioinformatics online.

AB - UNLABELLED: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project.AVAILABILITY AND IMPLEMENTATION: The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.CONTACT: [email protected] or [email protected] INFORMATION: Supplementary data are available at Bioinformatics online.

U2 - 10.1093/bioinformatics/btv491

DO - 10.1093/bioinformatics/btv491

M3 - Article (Academic Journal)

C2 - 26315906

SN - 1367-4811

VL - 31

SP - 4029

EP - 4031

JO - Bioinformatics

JF - Bioinformatics

IS - 24

ER -

An interactive genome browser of association results from the UK10K cohorts project

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Projects

MRC UoB UNITE Unit - Programme 1

MRC UoB UNITE Unit - programme 3

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