An outbreak of asthma in a modern detergent factory

P Cullinan; J M Harris; A J Newman Taylor; A M Hole; M Jones; F Barnes; G Jolliffe

An outbreak of asthma in a modern detergent factory

P Cullinan, J M Harris, A J Newman Taylor, A M Hole, M Jones, F Barnes, G Jolliffe

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

123 Citations (Scopus)

Abstract

The striking decrease in the occurrence of protease-induced occupational asthma in the detergent Industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in size to those reported in the 1960s, in a modem European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-Induced allergy and asthma.

Original language	English
Pages (from-to)	1899-900
Number of pages	2
Journal	Lancet
Volume	356
Issue number	9245
Publication status	Published - 2 Dec 2000

Keywords

Adolescent
Adult
Amylases
Asthma
Cellulase
Detergents
Disease Outbreaks
Endopeptidases
Europe
Female
Humans
Male
Middle Aged
Occupational Diseases
Occupational Exposure
Skin Tests

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title = "An outbreak of asthma in a modern detergent factory",

abstract = "The striking decrease in the occurrence of protease-induced occupational asthma in the detergent Industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in size to those reported in the 1960s, in a modem European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-Induced allergy and asthma.",

keywords = "Adolescent, Adult, Amylases, Asthma, Cellulase, Detergents, Disease Outbreaks, Endopeptidases, Europe, Female, Humans, Male, Middle Aged, Occupational Diseases, Occupational Exposure, Skin Tests",

author = "P Cullinan and Harris, {J M} and {Newman Taylor}, {A J} and Hole, {A M} and M Jones and F Barnes and G Jolliffe",

year = "2000",

month = dec,

day = "2",

language = "English",

volume = "356",

pages = "1899--900",

journal = "Lancet",

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publisher = "Lancet Publishing Group",

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TY - JOUR

T1 - An outbreak of asthma in a modern detergent factory

AU - Cullinan, P

AU - Harris, J M

AU - Newman Taylor, A J

AU - Hole, A M

AU - Jones, M

AU - Barnes, F

AU - Jolliffe, G

PY - 2000/12/2

Y1 - 2000/12/2

N2 - The striking decrease in the occurrence of protease-induced occupational asthma in the detergent Industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in size to those reported in the 1960s, in a modem European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-Induced allergy and asthma.

AB - The striking decrease in the occurrence of protease-induced occupational asthma in the detergent Industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in size to those reported in the 1960s, in a modem European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-Induced allergy and asthma.

KW - Adolescent

KW - Adult

KW - Amylases

KW - Asthma

KW - Cellulase

KW - Detergents

KW - Disease Outbreaks

KW - Endopeptidases

KW - Europe

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Occupational Diseases

KW - Occupational Exposure

KW - Skin Tests

M3 - Article (Academic Journal)

C2 - 11130389

SN - 0140-6736

VL - 356

SP - 1899

EP - 1900

JO - Lancet

JF - Lancet

IS - 9245

ER -

An outbreak of asthma in a modern detergent factory

Abstract

Keywords

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