An unusual presentation of vitamin D-dependent rickets type II in a kitten

Florent Duplan, Christina L Maunder

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
329 Downloads (Pure)


Case summary
A 15-week-old kitten presented with a 1-month history of intermittent generalized tremors and abdominal distension. Hypocalcaemia associated with increased 1,25- vitamin D3 was consistent with vitamin D3-dependent rickets type II. The bone appearance on CT scan was most consistent with the changes typically seen with nutritional secondary hyperparathyroidism and less typical of the changes seen with rickets. Our patient had a positive response to high vitamin D3 therapy as he remained normocalcaemic 16 months after diagnosis; supporting the diagnosis of rickets.

Relevance and novel information
This case report is an unusual and interesting presentation of rickets in a kitten. Despite the characteristic vitamin D3 disturbance for rickets type II, the atypical radiographic changes have not been previously reported. In the literature, a positive response to treatment is not commonly seen or follow up is short. Our case responded well to treatment and was followed for 16 months from the time of diagnosis. This emphasizes that the pathophysiology of the condition is not well understood, and that different types of vitamin D3-dependent rickets type II may exist. Although the genetic defects responsible for some cases of rickets type I have been identified, this has still not been determined for rickets type II.
Original languageEnglish
Number of pages7
JournalJournal of Feline Medicine and Surgery Open Reports
Issue number1
Early online date19 Mar 2020
Publication statusPublished - 27 Mar 2020


  • Rickets
  • calcium
  • vitamin D3
  • vitamin-D3-dependent rickets
  • osteomalacia


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