Analysing functional implications of differences in left ventricular morphology using statistical shape modelling

Froso Sophocleous; Lucy Standen; Gemina D Doolub; Reem Laymouna; Chiara Bucciarelli-Ducci; Massimo Caputo; Nathan E Manghat; Mark C K Hamilton; Stephanie L Curtis; Giovanni Biglino

Analysing functional implications of differences in left ventricular morphology using statistical shape modelling

Froso Sophocleous, Lucy Standen, Gemina D Doolub, Reem Laymouna, Chiara Bucciarelli-Ducci, Massimo Caputo, Nathan E Manghat, Mark C K Hamilton, Stephanie L Curtis, Giovanni Biglino

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Abstract

Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p

Original language	English
Article number	19163
Journal	Scientific Reports
Volume	12
Early online date	10 Nov 2022
Publication status	E-pub ahead of print - 10 Nov 2022

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title = "Analysing functional implications of differences in left ventricular morphology using statistical shape modelling",

abstract = "Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p ",

author = "Froso Sophocleous and Lucy Standen and Doolub, {Gemina D} and Reem Laymouna and Chiara Bucciarelli-Ducci and Massimo Caputo and Manghat, {Nathan E} and Hamilton, {Mark C K} and Curtis, {Stephanie L} and Giovanni Biglino",

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language = "English",

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journal = "Scientific Reports",

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T1 - Analysing functional implications of differences in left ventricular morphology using statistical shape modelling

AU - Sophocleous, Froso

AU - Standen, Lucy

AU - Doolub, Gemina D

AU - Laymouna, Reem

AU - Bucciarelli-Ducci, Chiara

AU - Caputo, Massimo

AU - Manghat, Nathan E

AU - Hamilton, Mark C K

AU - Curtis, Stephanie L

AU - Biglino, Giovanni

PY - 2022/11/10

Y1 - 2022/11/10

N2 - Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p

AB - Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p

M3 - Article (Academic Journal)

SN - 2045-2322

VL - 12

JO - Scientific Reports

JF - Scientific Reports

M1 - 19163

ER -

Analysing functional implications of differences in left ventricular morphology using statistical shape modelling

Abstract

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