This paper presents a mathematical model for a novel synthetic gene regulatory network. The aim of this circuit is to behave as a bistable switch for in vivo delivery of short hairpin RNA (shRNA) which can induce RNA interference (RNAi) of a target mRNA. Through the mathematical analysis performed here, it will be shown how the circuit can be controlled to induce sustained expression of a shRNA, with a transient input of two different inducer molecules.
|Title of host publication||2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010|
|Number of pages||4|
|Publication status||Published - 1 Dec 2010|
|Event||2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010 - Paphos, Cyprus|
Duration: 3 Nov 2010 → 5 Nov 2010
|Conference||2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010|
|Period||3/11/10 → 5/11/10|