Analysis and design of a versatile synthetic network for inducible gene expression in mammalian systems

A. Polynikis*, G. Cuccato, S. Criscuolo, S. J. Hogan, M. Di Bernardo, D. Di Bernardo

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Abstract

This paper presents a mathematical model for a novel synthetic gene regulatory network. The aim of this circuit is to behave as a bistable switch for in vivo delivery of short hairpin RNA (shRNA) which can induce RNA interference (RNAi) of a target mRNA. Through the mathematical analysis performed here, it will be shown how the circuit can be controlled to induce sustained expression of a shRNA, with a transient input of two different inducer molecules.

Original languageEnglish
Title of host publication2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010
Pages182-185
Number of pages4
DOIs
Publication statusPublished - 1 Dec 2010
Event2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010 - Paphos, Cyprus
Duration: 3 Nov 20105 Nov 2010

Conference

Conference2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010
CountryCyprus
CityPaphos
Period3/11/105/11/10

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    Polynikis, A., Cuccato, G., Criscuolo, S., Hogan, S. J., Di Bernardo, M., & Di Bernardo, D. (2010). Analysis and design of a versatile synthetic network for inducible gene expression in mammalian systems. In 2010 IEEE Biomedical Circuits and Systems Conference, BioCAS 2010 (pp. 182-185). [5709601] https://doi.org/10.1109/BIOCAS.2010.5709601