Analysis, design and implementation of a novel scheme for in-vivo control of synthetic gene regulatory networksstar, open

F. Menolascina, M Di Bernardo, D. di Bernardo

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Abstract

This paper is concerned with the design and implementation of a simple but effective switching control strategy to regulate the dynamics of synthetic gene networks. The testbed circuit is IRMA, a recently developed network in S. Cerevisiae which is proposed as a suitable benchmark problem for control design. The proof-of-concept of an implementation of the control strategy in vivo is presented which is based on the use of microfluidics devices and fluorescence microscopy. Preliminary experimental results are given showing the good matching between the model predictions and the experimental observations.
Translated title of the contributionAnalysis, design and implementation of a novel scheme for in-vivo control of synthetic gene regulatory networksstar, open
Original languageEnglish
Pages (from-to)1265 - 1270
Number of pages5
JournalAutomatica
Volume47 Issue 6
DOIs
Publication statusPublished - Jun 2011

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • synthetic biology

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