Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

Celia L. Gregson*, Margaret A. Paggiosi, Nicola Crabtree, Sue A. Steel, Eugene McCloskey, Emma L. Duncan, Bo Fan, John A. Shepherd, William D. Fraser, George Davey Smith, Jonathan H Tobias

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.

Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.

Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.

Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.

Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P

Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)

Original languageEnglish
Article number98(2)
Pages (from-to)818-828
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number2
Early online date21 Jan 2013
DOIs
Publication statusPublished - 1 Feb 2013

Keywords

  • PHYSICAL-ACTIVITY QUESTIONNAIRE
  • AUTOSOMAL-DOMINANT OSTEOPETROSIS
  • UNIVERSAL STANDARDIZATION
  • CIRCULATING SCLEROSTIN
  • POSTMENOPAUSAL WOMEN
  • PREMENOPAUSAL WOMEN
  • INSULIN SENSITIVITY
  • NATURAL-HISTORY
  • DXA SYSTEMS
  • DENSITY

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