Projects per year
Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.
Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.
Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.
Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.
Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P
Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)
- PHYSICAL-ACTIVITY QUESTIONNAIRE
- AUTOSOMAL-DOMINANT OSTEOPETROSIS
- UNIVERSAL STANDARDIZATION
- CIRCULATING SCLEROSTIN
- POSTMENOPAUSAL WOMEN
- PREMENOPAUSAL WOMEN
- INSULIN SENSITIVITY
- DXA SYSTEMS