Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

Celia L. Gregson; Margaret A. Paggiosi; Nicola Crabtree; Sue A. Steel; Eugene McCloskey; Emma L. Duncan; Bo Fan; John A. Shepherd; William D. Fraser; George Davey Smith; Jonathan H Tobias

doi:10.1210/jc.2012-3342

Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

Celia L. Gregson^*
, Margaret A. Paggiosi
, Nicola Crabtree
, Sue A. Steel
, Eugene McCloskey
, Emma L. Duncan
, Bo Fan
, John A. Shepherd
, William D. Fraser
, George Davey Smith
, Jonathan H Tobias

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

Abstract

Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.

Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.

Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.

Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.

Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P

Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)

Original language	English
Article number	98(2)
Pages (from-to)	818-828
Number of pages	10
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	98
Issue number	2
Early online date	21 Jan 2013
DOIs	https://doi.org/10.1210/jc.2012-3342
Publication status	Published - 1 Feb 2013

Keywords

PHYSICAL-ACTIVITY QUESTIONNAIRE
AUTOSOMAL-DOMINANT OSTEOPETROSIS
UNIVERSAL STANDARDIZATION
CIRCULATING SCLEROSTIN
POSTMENOPAUSAL WOMEN
PREMENOPAUSAL WOMEN
INSULIN SENSITIVITY
NATURAL-HISTORY
DXA SYSTEMS
DENSITY

Access to Document

10.1210/jc.2012-3342

http://jcem.endojournals.org/content/98/2/818

Handle.net

Persistent link

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research

Cite this

Gregson, C. L., Paggiosi, M. A., Crabtree, N., Steel, S. A., McCloskey, E., Duncan, E. L., Fan, B., Shepherd, J. A., Fraser, W. D., Smith, G. D., & Tobias, J. H. (2013). Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men. Journal of Clinical Endocrinology and Metabolism, 98(2), 818-828. Article 98(2). https://doi.org/10.1210/jc.2012-3342

@article{7d7bc66c0bd0406ea755a9955101f7cd,

title = "Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men",

abstract = "Context: High bone mass (HBM), detected in 0.2\% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95\% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, PConclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)",

keywords = "PHYSICAL-ACTIVITY QUESTIONNAIRE, AUTOSOMAL-DOMINANT OSTEOPETROSIS, UNIVERSAL STANDARDIZATION, CIRCULATING SCLEROSTIN, POSTMENOPAUSAL WOMEN, PREMENOPAUSAL WOMEN, INSULIN SENSITIVITY, NATURAL-HISTORY, DXA SYSTEMS, DENSITY",

author = "Gregson, \{Celia L.\} and Paggiosi, \{Margaret A.\} and Nicola Crabtree and Steel, \{Sue A.\} and Eugene McCloskey and Duncan, \{Emma L.\} and Bo Fan and Shepherd, \{John A.\} and Fraser, \{William D.\} and Smith, \{George Davey\} and Tobias, \{Jonathan H\}",

year = "2013",

month = feb,

day = "1",

doi = "10.1210/jc.2012-3342",

language = "English",

volume = "98",

pages = "818--828",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

number = "2",

}

Gregson, CL, Paggiosi, MA, Crabtree, N, Steel, SA, McCloskey, E, Duncan, EL, Fan, B, Shepherd, JA, Fraser, WD, Smith, GD & Tobias, JH 2013, 'Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 2, 98(2), pp. 818-828. https://doi.org/10.1210/jc.2012-3342

Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men. / Gregson, Celia L.; Paggiosi, Margaret A.; Crabtree, Nicola et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 98(2), 01.02.2013, p. 818-828.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

AU - Gregson, Celia L.

AU - Paggiosi, Margaret A.

AU - Crabtree, Nicola

AU - Steel, Sue A.

AU - McCloskey, Eugene

AU - Duncan, Emma L.

AU - Fan, Bo

AU - Shepherd, John A.

AU - Fraser, William D.

AU - Smith, George Davey

AU - Tobias, Jonathan H

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, PConclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)

AB - Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear.Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover.Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls.Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers.Results: Among women, fat mass was inversely related to age in controls(P=.01), but not in HBM cases(P=.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, PConclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. (J Clin Endocrinol Metab 98: 818-828, 2013)

KW - PHYSICAL-ACTIVITY QUESTIONNAIRE

KW - AUTOSOMAL-DOMINANT OSTEOPETROSIS

KW - UNIVERSAL STANDARDIZATION

KW - CIRCULATING SCLEROSTIN

KW - POSTMENOPAUSAL WOMEN

KW - PREMENOPAUSAL WOMEN

KW - INSULIN SENSITIVITY

KW - NATURAL-HISTORY

KW - DXA SYSTEMS

KW - DENSITY

U2 - 10.1210/jc.2012-3342

DO - 10.1210/jc.2012-3342

M3 - Article (Academic Journal)

C2 - 23337721

AN - SCOPUS:84873688870

SN - 0021-972X

VL - 98

SP - 818

EP - 828

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 2

M1 - 98(2)

ER -

Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Projects

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this