Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders

Roy M. Nilsen; Pal Suren; Nina Gunnes; Elin R. Alsaker; Michaeline Bresnahan; Deborah Hirtz; Mady Hornig; Kari Kveim Lie; W. Ian Lipkin; Ted Reichborn-Kjennerud; Christine Roth; Synnve Schjolberg; George Davey Smith; Ezra Susser; Stein Emil Vollset; Anne-Siri Oyen; Per Magnus; Camilla Stoltenberg

doi:10.1111/ppe.12077

Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders

Roy M. Nilsen^*, Pal Suren, Nina Gunnes, Elin R. Alsaker, Michaeline Bresnahan, Deborah Hirtz, Mady Hornig, Kari Kveim Lie, W. Ian Lipkin, Ted Reichborn-Kjennerud, Christine Roth, Synnve Schjolberg, George Davey Smith, Ezra Susser, Stein Emil Vollset, Anne-Siri Oyen, Per Magnus, Camilla Stoltenberg

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

81 Citations (Scopus)

Abstract

BackgroundThis study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs).

MethodsThe cohort sample (n=89836) was derived from the population-based prospective Norwegian Mother and Child Cohort Study and its substudy of ASDs, the Autism Birth Cohort (ABC) study. The nationwide registry data were derived from the Medical Birth Registry of Norway (n=507856). The children were born in 1999-2007, and seven prenatal and perinatal exposures were selected for analyses.

ResultsASDs were reported for 234 (0.26%) children in the cohort and 2072 (0.41%) in the nationwide population. Compared with the nationwide population, the cohort had an under-representation of the youngest women (

ConclusionsAssociations estimated between ASDs and perinatal and prenatal exposures in the cohort are close to those estimated in the nationwide population. Self-selection does not appear to compromise validity of exposure-outcome associations in the ABC study.

Original language	English
Pages (from-to)	553-563
Number of pages	11
Journal	Paediatric and Perinatal Epidemiology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1111/ppe.12077
Publication status	Published - Nov 2013

Keywords

Autism
cohort
Norway
pregnancy
selection bias
FOLIC-ACID SUPPLEMENTS
PERINATAL RISK-FACTORS
INFANTILE-AUTISM
CHILDREN
PARTICIPATION
ASSOCIATION
PREVALENCE
REGISTRY
CHARGE
DELAY

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10.1111/ppe.12077

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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

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Nilsen, R. M., Suren, P., Gunnes, N., Alsaker, E. R., Bresnahan, M., Hirtz, D., Hornig, M., Lie, K. K., Lipkin, W. I., Reichborn-Kjennerud, T., Roth, C., Schjolberg, S., Smith, G. D., Susser, E., Vollset, S. E., Oyen, A.-S., Magnus, P., & Stoltenberg, C. (2013). Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders. Paediatric and Perinatal Epidemiology, 27(6), 553-563. https://doi.org/10.1111/ppe.12077

@article{9e93500337754f8bbca31b3648940fa8,

title = "Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders",

abstract = "BackgroundThis study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs).MethodsThe cohort sample (n=89836) was derived from the population-based prospective Norwegian Mother and Child Cohort Study and its substudy of ASDs, the Autism Birth Cohort (ABC) study. The nationwide registry data were derived from the Medical Birth Registry of Norway (n=507856). The children were born in 1999-2007, and seven prenatal and perinatal exposures were selected for analyses.ResultsASDs were reported for 234 (0.26\%) children in the cohort and 2072 (0.41\%) in the nationwide population. Compared with the nationwide population, the cohort had an under-representation of the youngest women (ConclusionsAssociations estimated between ASDs and perinatal and prenatal exposures in the cohort are close to those estimated in the nationwide population. Self-selection does not appear to compromise validity of exposure-outcome associations in the ABC study.",

keywords = "Autism, cohort, Norway, pregnancy, selection bias, FOLIC-ACID SUPPLEMENTS, PERINATAL RISK-FACTORS, INFANTILE-AUTISM, CHILDREN, PARTICIPATION, ASSOCIATION, PREVALENCE, REGISTRY, CHARGE, DELAY",

author = "Nilsen, \{Roy M.\} and Pal Suren and Nina Gunnes and Alsaker, \{Elin R.\} and Michaeline Bresnahan and Deborah Hirtz and Mady Hornig and Lie, \{Kari Kveim\} and Lipkin, \{W. Ian\} and Ted Reichborn-Kjennerud and Christine Roth and Synnve Schjolberg and Smith, \{George Davey\} and Ezra Susser and Vollset, \{Stein Emil\} and Anne-Siri Oyen and Per Magnus and Camilla Stoltenberg",

year = "2013",

month = nov,

doi = "10.1111/ppe.12077",

language = "English",

volume = "27",

pages = "553--563",

journal = "Paediatric and Perinatal Epidemiology",

issn = "0269-5022",

publisher = "Wiley-Blackwell",

number = "6",

}

Nilsen, RM, Suren, P, Gunnes, N, Alsaker, ER, Bresnahan, M, Hirtz, D, Hornig, M, Lie, KK, Lipkin, WI, Reichborn-Kjennerud, T, Roth, C, Schjolberg, S, Smith, GD, Susser, E, Vollset, SE, Oyen, A-S, Magnus, P & Stoltenberg, C 2013, 'Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders', Paediatric and Perinatal Epidemiology, vol. 27, no. 6, pp. 553-563. https://doi.org/10.1111/ppe.12077

TY - JOUR

T1 - Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders

AU - Nilsen, Roy M.

AU - Suren, Pal

AU - Gunnes, Nina

AU - Alsaker, Elin R.

AU - Bresnahan, Michaeline

AU - Hirtz, Deborah

AU - Hornig, Mady

AU - Lie, Kari Kveim

AU - Lipkin, W. Ian

AU - Reichborn-Kjennerud, Ted

AU - Roth, Christine

AU - Schjolberg, Synnve

AU - Smith, George Davey

AU - Susser, Ezra

AU - Vollset, Stein Emil

AU - Oyen, Anne-Siri

AU - Magnus, Per

AU - Stoltenberg, Camilla

PY - 2013/11

Y1 - 2013/11

N2 - BackgroundThis study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs).MethodsThe cohort sample (n=89836) was derived from the population-based prospective Norwegian Mother and Child Cohort Study and its substudy of ASDs, the Autism Birth Cohort (ABC) study. The nationwide registry data were derived from the Medical Birth Registry of Norway (n=507856). The children were born in 1999-2007, and seven prenatal and perinatal exposures were selected for analyses.ResultsASDs were reported for 234 (0.26%) children in the cohort and 2072 (0.41%) in the nationwide population. Compared with the nationwide population, the cohort had an under-representation of the youngest women (ConclusionsAssociations estimated between ASDs and perinatal and prenatal exposures in the cohort are close to those estimated in the nationwide population. Self-selection does not appear to compromise validity of exposure-outcome associations in the ABC study.

AB - BackgroundThis study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs).MethodsThe cohort sample (n=89836) was derived from the population-based prospective Norwegian Mother and Child Cohort Study and its substudy of ASDs, the Autism Birth Cohort (ABC) study. The nationwide registry data were derived from the Medical Birth Registry of Norway (n=507856). The children were born in 1999-2007, and seven prenatal and perinatal exposures were selected for analyses.ResultsASDs were reported for 234 (0.26%) children in the cohort and 2072 (0.41%) in the nationwide population. Compared with the nationwide population, the cohort had an under-representation of the youngest women (ConclusionsAssociations estimated between ASDs and perinatal and prenatal exposures in the cohort are close to those estimated in the nationwide population. Self-selection does not appear to compromise validity of exposure-outcome associations in the ABC study.

KW - Autism

KW - cohort

KW - Norway

KW - pregnancy

KW - selection bias

KW - FOLIC-ACID SUPPLEMENTS

KW - PERINATAL RISK-FACTORS

KW - INFANTILE-AUTISM

KW - CHILDREN

KW - PARTICIPATION

KW - ASSOCIATION

KW - PREVALENCE

KW - REGISTRY

KW - CHARGE

KW - DELAY

U2 - 10.1111/ppe.12077

DO - 10.1111/ppe.12077

M3 - Article (Academic Journal)

C2 - 23919580

SN - 0269-5022

VL - 27

SP - 553

EP - 563

JO - Paediatric and Perinatal Epidemiology

JF - Paediatric and Perinatal Epidemiology

IS - 6

ER -

Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders

Abstract

Keywords

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MRC UoB UNITE Unit - Programme 1

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