Analytical detection and biological assay of antileukemic drug using gold nanoparticles

V. Selvaraj; M. Alagar; I. Hamerton

doi:10.1016/j.electacta.2006.07.016

Analytical detection and biological assay of antileukemic drug using gold nanoparticles

V. Selvaraj, M. Alagar^*, I. Hamerton

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

28 Citations (Scopus)

Abstract

Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 6-mercaptopurine (6-MP). The nature of binding between 6-MP and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 6-MP-colloidal gold complex is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.

Original language	English
Pages (from-to)	1152-1160
Number of pages	9
Journal	Electrochimica Acta
Volume	52
Issue number	3
DOIs	https://doi.org/10.1016/j.electacta.2006.07.016
Publication status	Published - 12 Nov 2006

Keywords

6-Mercaptopurine
Antibacterial and antifungal activity
Gold nanoparticles
Microbial studies

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title = "Analytical detection and biological assay of antileukemic drug using gold nanoparticles",

abstract = "Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 6-mercaptopurine (6-MP). The nature of binding between 6-MP and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 6-MP-colloidal gold complex is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.",

keywords = "6-Mercaptopurine, Antibacterial and antifungal activity, Gold nanoparticles, Microbial studies",

author = "V. Selvaraj and M. Alagar and I. Hamerton",

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T1 - Analytical detection and biological assay of antileukemic drug using gold nanoparticles

AU - Selvaraj, V.

AU - Alagar, M.

AU - Hamerton, I.

PY - 2006/11/12

Y1 - 2006/11/12

N2 - Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 6-mercaptopurine (6-MP). The nature of binding between 6-MP and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 6-MP-colloidal gold complex is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.

AB - Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 6-mercaptopurine (6-MP). The nature of binding between 6-MP and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 6-MP-colloidal gold complex is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.

KW - 6-Mercaptopurine

KW - Antibacterial and antifungal activity

KW - Gold nanoparticles

KW - Microbial studies

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DO - 10.1016/j.electacta.2006.07.016

M3 - Article (Academic Journal)

AN - SCOPUS:33749537287

VL - 52

SP - 1152

EP - 1160

JO - Electrochimica Acta

JF - Electrochimica Acta

SN - 0013-4686

IS - 3

ER -

Analytical detection and biological assay of antileukemic drug using gold nanoparticles

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