Analytical detection and biological assay of antileukemic drug using gold nanoparticles

V. Selvaraj, M. Alagar*, I. Hamerton

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)

Abstract

Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 6-mercaptopurine (6-MP). The nature of binding between 6-MP and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 6-MP-colloidal gold complex is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.

Original languageEnglish
Pages (from-to)1152-1160
Number of pages9
JournalElectrochimica Acta
Volume52
Issue number3
DOIs
Publication statusPublished - 12 Nov 2006

Keywords

  • 6-Mercaptopurine
  • Antibacterial and antifungal activity
  • Gold nanoparticles
  • Microbial studies

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