Angiogenesis in Tissue Engineering: As Nature Intended?

Valeria Mastrullo, William Cathery, Eirini Velliou, Paolo Madeddu, Paola Campagnolo

Research output: Contribution to journalReview article (Academic Journal)peer-review

89 Citations (Scopus)
127 Downloads (Pure)


Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.
Original languageEnglish
Article number188
Number of pages13
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 20 Mar 2020


  • scaffolds
  • spatio-temporal gradient
  • vessel maturation
  • angiogenesis
  • tissue engineering


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