Angiotensin converting enzyme (ACE) genotypes and disability in hospitalized older patients

D Seripa, G Paroni, MG Matera, C Gravina, C Scarcelli, M Corritore, LP D'Ambrosio, M Urbano, G D'Onofrio, M Copetti, PG Kehoe, F Panza, A Pilotto

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)

Abstract

The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
Translated title of the contributionAngiotensin converting enzyme (ACE) genotypes and disability in hospitalized older patients
Original languageEnglish
Pages (from-to)409 - 419
Number of pages10
JournalAGE
Volume33 (3)
DOIs
Publication statusPublished - Sep 2011

Bibliographical note

Publisher: Springer Netherlands

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