Animal models in overactive bladder research

Brian Parsons, Marcus Drake

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

48 Citations (Scopus)

Abstract

Overactive bladder syndrome (OAB) is a symptom-based diagnosis characterised by the presence of urinary urgency. It is highly prevalent and overlaps with the presence of bladder contractions during urine storage, which characterises the urodynamic diagnosis of detrusor overactivity. Animal models are needed to understand the pathophysiology of OAB, but the subjective nature of the symptomcomplex means that interpretation of the findings in animals requires caution. Because urinary urgency cannot be ascertained in animals, surrogate markers such as frequency, altered toileting areas, and non-micturition contractions have to be used instead. No model can recapitulate the subjective, objective, and related factors seen in the clinical setting. Models used include partial bladder outlet obstruction, the spontaneous hypertensive rat, the hyperlipidaemic rat, various neurological insults and some gene knock-outs. Strengths and weaknesses of these models are discussed in the context of the inherent difficulties of extrapolating subjective symptoms in animals.
Translated title of the contributionAnimal models in overactive bladder research
Original languageEnglish
Title of host publicationUrinary Tract
EditorsKE Andersson, Martin Michel
PublisherSpringer
Pages15 - 43
Number of pages29
ISBN (Electronic)978-3-642-16499-6
ISBN (Print)978-3-642-16498-9
DOIs
Publication statusPublished - 2011

Publication series

NameHandbook of Experimental Pharmacology
PublisherSpringer Berlin Heidelberg
Volume2011
ISSN (Print)0171-2004

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