Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.

Original languageEnglish
Pages (from-to)106-14
Number of pages9
JournalBiochemistry and Cell Biology
Volume89
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Animals
  • Anion Exchange Protein 1, Erythrocyte
  • Cytoskeleton
  • Erythrocytes
  • Humans
  • Kidney Glomerulus
  • Kidney Tubules, Distal
  • Membrane Proteins
  • Models, Molecular
  • Podocytes
  • Protein Conformation
  • Protein Isoforms
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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