Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

Fiona Wu; Timothy J Satchwell; Ashley M Toye

doi:10.1139/o10-146

Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

Fiona Wu, Timothy J Satchwell, Ashley M Toye

Research output: Contribution to journal › Article (Academic Journal) › peer-review

24 Citations (Scopus)

Abstract

The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.

Original language	English
Pages (from-to)	106-14
Number of pages	9
Journal	Biochemistry and Cell Biology
Volume	89
Issue number	2
DOIs	https://doi.org/10.1139/o10-146
Publication status	Published - Apr 2011

Keywords

Animals
Anion Exchange Protein 1, Erythrocyte
Cytoskeleton
Erythrocytes
Humans
Kidney Glomerulus
Kidney Tubules, Distal
Membrane Proteins
Models, Molecular
Podocytes
Protein Conformation
Protein Isoforms
Journal Article
Research Support, Non-U.S. Gov't
Review

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title = "Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod",

abstract = "The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.",

keywords = "Animals, Anion Exchange Protein 1, Erythrocyte, Cytoskeleton, Erythrocytes, Humans, Kidney Glomerulus, Kidney Tubules, Distal, Membrane Proteins, Models, Molecular, Podocytes, Protein Conformation, Protein Isoforms, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "Fiona Wu and Satchwell, {Timothy J} and Toye, {Ashley M}",

year = "2011",

month = apr,

doi = "10.1139/o10-146",

language = "English",

volume = "89",

pages = "106--14",

journal = "Biochemistry and Cell Biology",

issn = "0829-8211",

publisher = "NRC Research Press",

number = "2",

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TY - JOUR

T1 - Anion exchanger 1 in red blood cells and kidney

T2 - Band 3's in a pod

AU - Wu, Fiona

AU - Satchwell, Timothy J

AU - Toye, Ashley M

PY - 2011/4

Y1 - 2011/4

N2 - The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.

AB - The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. A truncated kidney isoform (kAE1) is highly expressed in type A intercalated cells of the distal tubules, where it is vital for urinary acidification. Recently, kAE1 has emerged as a novel physiologically significant protein in the kidney glomerulus. This minireview will discuss the known interactions of kAE1 in the podocytes and the possible mechanisms whereby this important multispanning membrane protein may contribute to the function of the glomerular filtration barrier and prevent proteinuria.

KW - Animals

KW - Anion Exchange Protein 1, Erythrocyte

KW - Cytoskeleton

KW - Erythrocytes

KW - Humans

KW - Kidney Glomerulus

KW - Kidney Tubules, Distal

KW - Membrane Proteins

KW - Models, Molecular

KW - Podocytes

KW - Protein Conformation

KW - Protein Isoforms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1139/o10-146

DO - 10.1139/o10-146

M3 - Article (Academic Journal)

C2 - 21455263

SN - 0829-8211

VL - 89

SP - 106

EP - 114

JO - Biochemistry and Cell Biology

JF - Biochemistry and Cell Biology

IS - 2

ER -

Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

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Keywords

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