Antenatal vaccination against Group B streptococcus: Attitudes of pregnant women and healthcare professionals in the UK to participation in clinical trials and routine implementation

Adam Finn, Fiona McQuaid

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
218 Downloads (Pure)

Abstract

Introduction Maternal vaccination is increasingly part of antenatal care in the UK and worldwide. Trials of Group B streptococcus vaccines are ongoing. This study investigated the attitudes of pregnant women and healthcare professionals towards antenatal vaccination, both in routine care and a clinical trial setting. Material and methods Survey of 269 pregnant women, 273 midwives/obstetricians and 97 neonatal doctors across seven sites in the UK assessing attitudes towards antenatal vaccinations, knowledge of Group B streptococcus, a hypothetical Group B streptococcus vaccine, and participation in clinical vaccine trials. Results 68% of pregnant women intended to receive a vaccine during their current pregnancy (183/269) and 43% (of all respondents, 115/269) reported they would be very/fairly likely to accept a vaccine against Group B streptococcus despite only 29% (55/269) knowing what Group B streptococcus was. This increased to 69% after additional information about Group B streptococcus was provided. Twenty-four percent of pregnant women reported they would be likely to take part in a clinical trial of an unlicensed Group B streptococcus vaccine. Fifty-nine percent of maternity professionals and 74% of neonatologists would be likely to recommend participation in a Group B streptococcus vaccine trial to women, with the vast majority (>99%) willing to be involved in such a study. Incentives to take part cited by pregnant women included extra antenatal scans and the opportunity to be tested for Group B streptococcus. Conclusion Pregnant women and healthcare professionals were open to the idea of an antenatal Group B streptococcus vaccine and involvement in clinical trials of such a vaccine. Education and support from midwives would be key to successful implementation.
Original languageEnglish
Pages (from-to)330-340
Number of pages10
JournalActa Obstetricia et Gynecologica Scandinavica
Volume97
Issue number3
Early online date19 Jan 2018
DOIs
Publication statusPublished - 9 Mar 2018

Keywords

  • Group B streptococcus
  • antenatal vaccine
  • pregnancy
  • attitudes
  • healthcare professionals
  • pregnant women
  • clinical trials

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