Anthracene Bisureas as Powerful and Accessible Anion Carriers

Christopher M. Dias, Hennie Valkenier*, Anthony P. Davis

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)
248 Downloads (Pure)


Synthetic anion carriers (anionophores) have potential as biomedical research tools and as treatments for conditions arising from defective natural transport systems (notably cystic fibrosis). Highly active anionophores that are readily accessible and easily deliverable are especially valuable. Previous work has resulted in steroid and trans-decalin based anionophores with exceptional activity for chloride/nitrate exchange in vesicles, but poor accessibility and deliverability. This work shows that anthracene 1,8-bisureas can fulfil all three criteria. In particular, a bis-nitrophenyl derivative is prepared in two steps from commercial starting materials, yet shows comparable transport activity to the best currently known. Moreover, unlike earlier highly active systems, it does not need to be preincorporated in test vesicles but can be introduced subsequent to vesicle formation. This transporter also shows the ability to transfer between vesicles, and is therefore uniquely effective for anion transport at low transporter loadings. The results suggest that anthracene bisureas are promising candidates for application in biological research and medicine.

Original languageEnglish
Pages (from-to)6262-6268
Number of pages7
JournalChemistry - A European Journal
Issue number23
Early online date6 Apr 2018
Publication statusPublished - 20 Apr 2018

Structured keywords

  • BCS and TECS CDTs


  • anion transport
  • membranes
  • receptors
  • supramolecular chemistry
  • ureas


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