Anti-TNF-alpha reduces the inflammatory reaction associated with cuff electrode implantation around the sciatic nerve

V Vince, M.E. Brelen, J. Delbeke, I.M. Colin

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

Extraneural cuff electrodes have been extensively used to investigate the nervous system. Their implantation is, however, associated with epineurial fibrosis, fiber loss, limited reproducibility of recordings and variability in stimulating conditions. It has recently been shown that TNF-alpha is involved in nerve alterations after electrode implantation. This study investigated whether a peri-operative anti-TNF-alpha treatment could modify the inflammation and fibrosis associated with cuff electrode implantation. Morphometrical and immunohistochemical methods were used to show that a single systemic injection of TNF-alpha neutralizing antibodies is sufficient to reduce the early inflammatory events, but not the long lasting fibrotic reaction.
Translated title of the contributionAnti-TNF-alpha reduces the inflammatory reaction associated with cuff electrode implantation around the sciatic nerve
Original languageEnglish
Pages (from-to)121 - 128
JournalJournal of Neuroimmunology
Volume165 (1-2)
Publication statusPublished - 2005

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